Effects of Anthocyanin Extracts from Bilberry ( Vaccinium myrtillus L.) and Purple Potato ( Solanum tuberosum L. var. 'Synkeä Sakari') on the Plasma Metabolomic Profile of Zucker Diabetic Fatty Rats.

Autor:	Chen K; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland., Wei X; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100191, China., Zhang J; Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China., Pariyani R; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland., Jokioja J; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland., Kortesniemi M; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland., Linderborg KM; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland., Heinonen J; School of Engineering Science, Lappeenranta University of Technology, Lappeenranta FI-53850, Finland., Sainio T; School of Engineering Science, Lappeenranta University of Technology, Lappeenranta FI-53850, Finland., Zhang Y; Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China., Yang B; Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turun yliopisto, Turku FI-20014, Finland.
Jazyk:	angličtina
Zdroj:	Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Sep 02; Vol. 68 (35), pp. 9436-9450. Date of Electronic Publication: 2020 Aug 20.
DOI:	10.1021/acs.jafc.0c04125
Abstrakt:	This study compared the effects of the nonacylated and acylated anthocyanin-rich extracts on plasma metabolic profiles of Zucker diabetic fatty rats. The rats were fed with the nonacylated anthocyanin extract from bilberries (NAAB) or the acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. 1 H NMR metabolomics was used to study the changes in plasma metabolites. A reduced fasting plasma glucose level was seen in all anthocyanin-fed groups, especially in the groups fed with NAAB. Both NAAB and AAPP decreased the levels of branched-chain amino acids and improved lipid profiles. AAPP increased the glutamine/glutamate ratio and decreased the levels of glycerol and metabolites involved in glycolysis, suggesting improved insulin sensitivity, gluconeogenesis, and glycolysis. AAPP decreased the hepatic TBC1D1 and G6PC messenger RNA level, suggesting regulation of gluconeogenesis and lipogenesis. This study indicated that AAPP and NAAB affected the plasma metabolic profile of diabetic rats differently.
Databáze:	MEDLINE
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