Salt-dependent hypertension and inflammation: targeting the gut-brain axis and the immune system with Brazilian green propolis.

Autor: Batista MAC; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil., Braga DCA; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil., de Moura SAL; Department of Environmental Engineering, Mines School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil., de Souza GHB; Department of Pharmacy, Pharmacy School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Dos Santos ODH; Department of Pharmacy, Pharmacy School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Cardoso LM; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil. leonardo.cardoso@ufop.edu.br.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2020 Oct; Vol. 28 (5), pp. 1163-1182. Date of Electronic Publication: 2020 Aug 12.
DOI: 10.1007/s10787-020-00742-2
Abstrakt: Systemic arterial hypertension (SAH) is a major health problem around the world and its development has been associated with exceeding salt consumption by the modern society. The mechanisms by which salt consumption increase blood pressure (BP) involve several homeostatic systems but many details have not yet been fully elucidated. Evidences accumulated over the last 60 decades raised the involvement of the immune system in the hypertension development and opened a range of possibilities for new therapeutic targets. Green propolis is a promising natural product with potent anti-inflammatory properties acting on specific targets, most of them participating in the gut-brain axis of the sodium-dependent hypertension. New anti-hypertensive products reinforce the therapeutic arsenal improving the corollary of choices, especially in those cases where patients are resistant or refractory to conventional therapy. This review sought to bring the newest advances in the field articulating evidences that show a cross-talking between inflammation and the central mechanisms involved with the sodium-dependent hypertension as well as the stablished actions of green propolis and some of its biologically active compounds on the immune cells and cytokines that would be involved with its anti-hypertensive properties.
Databáze: MEDLINE
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