Fosfomycin, Applying Known Methods and Remedies to A New Era.

Autor:	M VA; Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigación en Salud Pública 'Leopoldo Izquieta Pérez', Quito 170403, Ecuador.; Instituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador., Mariño-Brito E; Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador., Villavicencio F; Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigación en Salud Pública 'Leopoldo Izquieta Pérez', Quito 170403, Ecuador., Satán C; Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigación en Salud Pública 'Leopoldo Izquieta Pérez', Quito 170403, Ecuador., Villacís JE; Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador., Gestal MC; Health Science Center, Louisiana State University (LSU), Shreveport, LA 71103, USA.
Jazyk:	angličtina
Zdroj:	Diseases (Basel, Switzerland) [Diseases] 2020 Aug 07; Vol. 8 (3). Date of Electronic Publication: 2020 Aug 07.
DOI:	10.3390/diseases8030031
Abstrakt:	The exponential increase in the numbers of isolates of Carbapenem-Resistant Enterobacteriaceae (CRE) creates the need for using novel therapeutic approaches to save the lives of patients. Fosfomycin has long been considered a rational option for the treatment of CRE to be used as part of a combined therapy scheme. However, the assessment of fosfomycin susceptibility in the laboratory presents a great challenge due to the discrepancies found between different methodologies. Thus, our goal was to evaluate fosfomycin susceptibility in a group of 150 Enterobacteriaceae bacterial isolates using agar dilution as the gold standard technique to compare the results with those obtained by disk diffusion. We found a fosfomycin susceptibility of 79.3% in general terms. By comparing both methodologies, we reported a categorical agreement of 96% without Very Major Errors (VMEs) or Major Errors (MEs) and 4% of minor Errors (mEs). Our results suggest that fosfomycin could provide a rational alternative treatment for those patients that are infected by a Multidrug-Resistant (MDR) microorganism that is currently untreatable and that the disk diffusion and classical agar dilution techniques are adequate to assess the resistance profile of CRE to fosfomycin.
Databáze:	MEDLINE
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