Generalized Aggressive Periodontitis in a Patient With Nephrotic Syndrome Associated With Primary Renal Amyloidosis: A Case Report.

Autor: Fentoğlu Ö; Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey., Günhan M; Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey., Kürkçüoğlu I; Department of Prosthodontics, Faculty of Dentistry, Süleyman Demirel University., Gürgan CA; Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey., Sezer MT; Department of Nephrology, Faculty of Medicine, Süleyman Demirel University., Günhan Ö; Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Clinical advances in periodontics [Clin Adv Periodontics] 2014 Nov; Vol. 4 (4), pp. 226-233.
DOI: 10.1902/cap.2013.110086
Abstrakt: Introduction: Renal amyloidosis may lead to renal disease, and then nephrotic syndrome may develop. To the best of the authors' knowledge, this is the first case report in which a patient presents with generalized aggressive periodontitis (GAgP) and nephrotic syndrome in conjunction with renal amyloidosis.
Case Presentation: An 18-year-old male presented to the periodontology department for generalized gingival recessions. He was diagnosed as having primary renal amyloidosis by his physician. The patient presented with severe gingival inflammation and alveolar bone loss. Biochemical tests were within normal limits except for serum albumin level. No amyloid deposition was found in a gingival biopsy, and the patient was diagnosed as having GAgP. Non-surgical periodontal treatment, in combination with antibiotic treatment, was performed. After 3 years, his systemic and periodontal conditions showed deterioration.
Conclusions: The effects of systemic factors related to nephrotic syndrome in conjunction with renal amyloidosis and deterioration in oral hygiene may play a significant role in the progression of periodontal disease. Even if there is no amyloid deposition in periodontal tissues, clinicians should consider that nephrotic syndrome associated with systemic amyloidosis may provide an important contribution to the periodontal breakdown by the modifying conditions that affect the host response to the accumulation of dental biofilm.
(© 2014 American Academy of Periodontology.)
Databáze: MEDLINE
Externí odkaz: