Metabolomic profiling for juvenile Chinook salmon exposed to contaminants of emerging concern.

Autor: Meador JP; Ecotoxicology Program, Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, WA 98112, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA. Electronic address: james.meador@noaa.gov., Bettcher LF; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA., Ellenberger MC; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA., Senn TD; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2020 Dec 10; Vol. 747, pp. 141097. Date of Electronic Publication: 2020 Jul 24.
DOI: 10.1016/j.scitotenv.2020.141097
Abstrakt: Both targeted and non-targeted metabolomic analyses were conducted on juvenile ocean-type fall Chinook salmon (Oncorhynchus tshawytscha) residing in two estuaries receiving wastewater treatment plant (WWTP) effluent and one reference estuary. The data show that the metabolome patterns for fish from the two WWTP-receiving estuaries were more similar to each other compared to that for the reference site fish. Also, a comparison of the metabolome for fish from the reference site and fish from a hatchery upstream of one of the effluent-receiving estuaries indicated no differences, implying that residency for fish in the contaminated estuary resulted in major changes to the metabolome. Based on general health parameters including whole-body lipid content and condition factor, plus the availability of prey for these fish, we conclude that juvenile Chinook salmon in these contaminated estuaries may have been experiencing metabolic disruption without any overt signs of impairment. Additionally, a non-targeted analysis was performed on hatchery summer Chinook salmon from a laboratory study where fish were dosed for 32 days with feed containing 16 of the most common contaminants of emerging concern (CECs) detected in wild fish. In the laboratory experiment a relationship was observed between dose and the number of liver metabolites that were different between control and treatment fish. Laboratory fish were exposed to only 16 CECs, but are generally exposed to hundreds of these compounds in contaminated aquatic environments. These results have implications for the health of juvenile Chinook salmon and the likelihood of a successful life cycle when exposed to effluent-related chemicals.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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