Strength of patient cohorts and biobanks for cardiomyopathy research.

Autor: de Boer RA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Nijenkamp LLAM; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Silljé HHW; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Eijgenraam TR; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Parbhudayal R; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., van Driel B; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Huurman R; Department of Cardiology, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands., Michels M; Department of Cardiology, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands., Pei J; Department of Cardiology, Division Heart & Lungs, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Harakalova M; Department of Cardiology, Division Heart & Lungs, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., van Lint FHM; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Jansen M; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Baas AF; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., van Tintelen JP; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Brundel BJJM; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Dorsch LM; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Schuldt M; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Kuster DWD; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., van der Velden J; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. j.vandervelden1@amsterdamumc.nl.
Jazyk: angličtina
Zdroj: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation [Neth Heart J] 2020 Aug; Vol. 28 (Suppl 1), pp. 50-56.
DOI: 10.1007/s12471-020-01456-4
Abstrakt: In 2011 the Netherlands Heart Foundation allocated funding (CVON, Cardiovasculair Onderzoek Nederland) to stimulate collaboration between clinical and preclinical researchers on specific areas of research. One of those areas involves genetic heart diseases, which are frequently caused by pathogenic variants in genes that encode sarcomere proteins. In 2014, the DOSIS (Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches) consortium was initiated, focusing their research on secondary disease hits involved in the onset and progression of cardiomyopathies. Here we highlight several recent observations from our consortium and collaborators which may ultimately be relevant for clinical practice.
Databáze: MEDLINE
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