Senna (Cassia) alata (Linn.) Roxb. leaf decoction as a treatment for tinea imbricata in an indigenous tribe in Southern Philippines.

Autor: Eusebio-Alpapara KMV; Department of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines., Dofitas BL; Department of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines., Balita-Crisostomo CLA; Department of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines., Tioleco-Ver GMS; Department of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines., Jandoc LE; Rural Health Unit, Municipality of Kiamba, Philippines., Frez MLF; Department of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Jazyk: angličtina
Zdroj: Mycoses [Mycoses] 2020 Nov; Vol. 63 (11), pp. 1226-1234. Date of Electronic Publication: 2020 Sep 09.
DOI: 10.1111/myc.13159
Abstrakt: Background: Tinea imbricata, a rare form of tinea corporis caused by Trichophyton concentricum, is endemic to the T'boli tribe in the Southern Philippines. Temporary remissions and limited access to antifungal medications make its treatment a pressing public health concern. Anecdotal reports about the use of Senna alata leaf decoction as treatment exist.
Objective: To determine the efficacy of community-prepared S alata leaf decoction in the treatment of tinea imbricata.
Methods: Tinea imbricata patients were instructed to apply S alata leaf decoction for 4 weeks (28 ± 3 days). Disease severity, pruritus visual analogue scale scores (VAS) and potassium hydroxide (KOH) mounts of skin scrapings were evaluated before and after treatment. Two assessors evaluated disease severity based on photographs. Cohen's kappa statistics were used to assess diagnostic concordance. Adverse drug events were recorded.
Results: Twenty patients were enrolled. After 4 weeks, 95% had decreased pruritus VAS scores, with a mean decreased of 4.05 after treatment (P < .0001). There was a significant difference in disease severity scores before and after treatment (P ≤ .05) with an overall agreement of 'moderate' for both assessors (κ = 0.6, 95% CI [0.33, 0.87]). Forty per cent had negative KOH tests after treatment. None had adverse drug events.
Conclusion: This is the first study that showed the potential of a community-prepared leaf decoction as a treatment option for tinea imbricata. Larger clinical trials establishing its efficacy, effectiveness and safety profile are recommended to enable its promotion among the indigenous people and health authorities as an accessible and affordable treatment for tinea imbricata.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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