Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis.

Autor:	Stepniewska K; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory, Oxford, United Kingdom., Humphreys GS; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory, Oxford, United Kingdom.; Green Templeton College, University of Oxford, Oxford, United Kingdom., Gonçalves BP; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom., Craig E; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory, Oxford, United Kingdom., Gosling R; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.; Global Health Group, Malaria Elimination Initiative, University of California, San Francisco, California, USA., Guerin PJ; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Infectious Diseases Data Observatory, Oxford, United Kingdom., Price RN; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Norther Territory, Australia.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Barnes KI; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.; University of Cape Town/Medical Research Council Collaborating Centre for Optimising Antimalarial Therapy, University of Cape Town, Cape Town, South Africa.; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Raman J; University of Cape Town/Medical Research Council Collaborating Centre for Optimising Antimalarial Therapy, University of Cape Town, Cape Town, South Africa.; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa.; Wits Research Institute for Malaria, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa., Smit MR; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., D'Alessandro U; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, London, United Kingdom., Stone WJR; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands., Bjorkman A; Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Samuels AM; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Centers for Disease Control and Prevention, Kisumu, Kenya., Arroyo-Arroyo MI; Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia., Bastiaens GJH; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Microbiology and Immunology, Rijnstate Hospital, Arnhem, the Netherlands., Brown JM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA., Dicko A; Malaria Research and Training Centre, Faculty of Pharmacy and Faculty of Medicine and Dentistry, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali., El-Sayed BB; Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan., Elzaki SG; Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan., Eziefula AC; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, United Kingdom., Kariuki S; Kenya Medical Research Institute, Kisian, Kenya., Kwambai TK; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Kenya Medical Research Institute, Kisian, Kenya., Maestre AE; Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia., Martensson A; Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden., Mosha D; Bagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.; Africa Academy for Public Health, Dar es Salaam, Tanzania., Mwaiswelo RO; Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Ngasala BE; Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Okebe J; Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Roh ME; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.; Global Health Group, Malaria Elimination Initiative, University of California, San Francisco, California, USA., Sawa P; Human Health Division, International Centre for Insect Physiology and Ecology, Mbita Point, Kenya., Tiono AB; Department of Biomedical Sciences, Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Chen I; Global Health Group, Malaria Elimination Initiative, University of California, San Francisco, California, USA., Drakeley CJ; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom., Bousema T; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Apr 01; Vol. 225 (7), pp. 1215-1226.
DOI:	10.1093/infdis/jiaa498
Abstrakt:	Background: Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to assess efficacy. Methods: An individual patient meta-analysis to assess gametocytocidal and transmission-blocking efficacy of PQ in combination with different ACTs was conducted. Random effects logistic regression was used to quantify PQ effect on (1) gametocyte carriage in the first 2 weeks post treatment; and (2) the probability of infecting at least 1 mosquito or of a mosquito becoming infected. Results: In 2574 participants from 14 studies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients presenting with gametocytemia on day 0 (odds ratio [OR], 0.22; 95% confidence interval [CI], .17-.28 and OR, 0.12; 95% CI, .08-.16, respectively). Rate of decline in gametocyte carriage was faster when PQ was combined with artemether-lumefantrine (AL) compared to dihydroartemisinin-piperaquine (DP) (P = .010 for day 7). Addition of 0.25 mg/kg PQ was associated with near complete prevention of transmission to mosquitoes. Conclusions: Transmission blocking is achieved with 0.25 mg/kg PQ. Gametocyte persistence and infectivity are lower when PQ is combined with AL compared to DP. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
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