Primary Intracranial Angiomatoid Fibrous Histiocytoma: Two Case Reports and Literature Review.

Autor: Bin Abdulqader S; Department of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address: binabdulqader@gmail.com., Altuhaini K; Department of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Tallab R; Histopathology, Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia., AlTurkistani A; Department of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Alhussinan M; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alghamdi S; College of Medicine, Tabuk University, Tabuk, Saudi Arabia., Al Saidi K; Cytogenetic, Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia., Almalki S; Histopathology, Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia., Alshakweer W; Histopathology, Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia., Alotaibi FE; Department of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2020 Nov; Vol. 143, pp. 398-404. Date of Electronic Publication: 2020 Aug 07.
DOI: 10.1016/j.wneu.2020.07.225
Abstrakt: Background: Angiomatoid fibrous histiocytoma (AFH) is a rare, fibrohistiocytic, soft-tissue neoplasm. Intracranial AFH is extremely rare. Here we present 2 pediatric cases of intracranial AFH and perform a literature review on this disease entity.
Case Description: We present 2 cases. The first case is a 10-year-old boy who presented with seizures and hemiparesis. The second case is an 11-year-old girl who presented with 2-year history of seizures. Radiologic images demonstrated right frontal lesions in both patients. Complete surgical resection was achieved. Histopathological findings established the diagnosis of intracranial AFH confirmed with fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction testing that demonstrated EWSR1 gene rearrangement in both cases.
Conclusions: Twenty-two cases of intracranial AFH have been previously documented, with the majority of lesions located in the frontal lobe. Most cases occurred in adolescents and young adults, with a slight female predilection. Headaches and seizures constituted the most common clinical presentation. Complete surgical resection remains the standard of care in the management of this pathology.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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