Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer.
| Autor: | Fliegel L; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada. lfliegel@ualberta.ca. |
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| Jazyk: | angličtina |
| Zdroj: | Reviews of physiology, biochemistry and pharmacology [Rev Physiol Biochem Pharmacol] 2022; Vol. 182, pp. 85-110. |
| DOI: | 10.1007/112_2020_18 |
| Abstrakt: | Prostate cancer is the fourth most commonly diagnosed cancer, and although it is often a slow-growing malignancy, it is the second leading cause of cancer-associated deaths in men and the first in Europe and North America. In many forms of cancer, when the disease is a solid tumor confined to one organ, it is often readily treated. However, when the cancer becomes an invasive metastatic carcinoma, it is more often fatal. It is therefore of great interest to identify mechanisms that contribute to the invasion of cells to identify possible targets for therapy. During prostate cancer progression, the epithelial cells undergo epithelial-mesenchymal transition that is characterized by morphological changes, a loss of cell-cell adhesion, and invasiveness. Dysregulation of pH has emerged as a hallmark of cancer with a reversed pH gradient and with a constitutively increased intracellular pH that is elevated above the extracellular pH. This phenomenon has been referred to as "a perfect storm" for cancer progression. Acid-extruding ion transporters include the Na + /H + exchanger NHE1 (SLC9A1), the Na + HCO (© 2020. Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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