[Prevalence of lymph node involvement in patients with endometrial cancer, Colombia 2009-2016: Exploratory analysis of associated factors].

Autor: Fernández-Mercado RS; Unidad de Ginecología Oncológica, Misión Médica, Clínica Bonnadona, Prevenir, Clínica Julio Enrique Medrano, Barranquilla (Colombia)., Miranda-Mejía MA; Universidad del Norte. Barranquilla (Colombia)., Fletcher-Prieto AV; Centro de Investigaciones Oncológicas, Clínica San Diego (CIOSAD), Bogotá (Colombia)., Rodríguez-Gallego JA; Hospital Manuel Uribe Ángel, Medellín (Colombia)., Mora-Padilla E; Hospital San José. Bogotá (Colombia)., Orostegui-Correa S; Clínica San Luis, Bucaramanga (Colombia)., González-Rubio de la Hoz Á; Unidad de Ginecología Oncológica, Misión Médica. Barranquilla (Colombia)., Vallejo-Bertel CA; Fundación Universitaria de Ciencias de la Salud. Bogotá (Colombia)., Sáenz-Salazar J; Instituto Nacional de Cancerología. Bogotá (Colombia)., Fernández-Cásseres MA; Unidad de Ginecología oncológica, Misión Médica. Barranquilla (Colombia)., Flórez-Lozano KC; Universidad del Norte, Barranquilla (Colombia)., Navarro-Lechuga É; Universidad del Norte, Barranquilla (Colombia).
Jazyk: Spanish; Castilian
Zdroj: Revista colombiana de obstetricia y ginecologia [Rev Colomb Obstet Ginecol] 2020 Jun; Vol. 71 (2), pp. 103-114.
DOI: 10.18597/rcog.3450
Abstrakt: Objective: To determine the prevalence of lymph node involvement in patients with endometrial cancer and to explore factors associated with lymph node invasion.
Methods: Prevalence study with exploratory analysis. The study included patients with endometrial cancer who underwent total abdominal hysterectomy plus bilateral salpyingooophorectomy and pelvic lymphadenectomy with or without para-aortic lymphadenectomy in seven oncology centers in Colombia between 2009 and 2016. Patients who had received prior radiotherapy or chemotherapy, with a histological diagnosis of neuroendocrine tumors, carcinosarcomas or synchronous or metachronous lesions were excluded. Non-probabilistic sampling. Sample size n=290. Measured variables: sociodemographic, clinical and histopathological, and pelvic or para-aortic lymph node involvement. The prevalence for the period is presented. The exploratory analysis was conducted using crude odds ratio (OR) and adjusted OR by means of a multivariate model (unconditional logistic regression).
Results: Overall, 467 cases were retrieved. Of them, 163 were excluded because of non-availability of all the variables. In total, 304 patients were studied. The prevalence of lymph node involvement was 15.8 % (48/304). In the crude and adjusted analysis, factors associated with lymph node involvement were lymphovascular invasion (adjusted OR: 9.32; 95 % CI 4.27-21.15) and myometrial invasion (adjusted OR: 3.95; 95 % CI 1.29-14.98).
Conclusions: Of the patients undergoing lymphadenectomy, 15 % have lymph node involvement. Less invasive diagnostic options than radical surgery to ascertain lymph node invasion should be assessed.
Competing Interests: None declared
(Copyright© 2020 This is an open-access article distributed under the terms of the Creative Commons Attribution License by-nc-nd/4.0.)
Databáze: MEDLINE
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