Assessment of bone healing using (Ti,Mg)N thin film coated plates and screws: Rabbit femur model.

Autor: Sabouni K; Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Ozturk Y; Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey., Kacar E; Department of Metallurgical and Materials Engineering, Istanbul Technical University, Istanbul, Turkey., Mutlu HS; Department of Histology and Embryology, Istanbul University, Istanbul, Turkey., Solakoglu S; Department of Histology and Embryology, Istanbul University, Istanbul, Turkey., Kose GT; Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Kok FN; Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey., Kazmanli MK; Department of Metallurgical and Materials Engineering, Istanbul Technical University, Istanbul, Turkey., Urgen KM; Department of Metallurgical and Materials Engineering, Istanbul Technical University, Istanbul, Turkey., Onder S; Department of Biomedical Engineering, Yildiz Technical University, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2021 Feb; Vol. 109 (2), pp. 227-237. Date of Electronic Publication: 2020 Aug 07.
DOI: 10.1002/jbm.b.34694
Abstrakt: Magnesium (Mg) based implants such as plates and screws are often preferred to treat bone defects because of the positive effects of magnesium in bone growth and healing. Their low corrosion resistance, however, leads to fast degradation and consequently failure before healing was completed. Previously, we developed Mg doped titanium nitrate (TiN) thin film coatings to address these limitations and demonstrated that <10 at% Mg doping led to enhanced mineralization in vitro. In the present study, in vivo performance of (Ti,Mg)N coated Ti6Al4V based plates and screws were studied in the rabbit model. Bone fractures were formed on femurs of 16 rabbits and then fixed with either (Ti,Mg)N coated (n = 8) or standard TiN coated (n = 8) plates and screws. X-ray imaging and μCT analyses showed enhanced bone regeneration on fracture sites fixed with (Ti,Mg)N coated plates in comparison with the Mg free ones. Bone mineral density, bone volume, and callus volume were also found to be 11.4, 23.4, and 42.8% higher, respectively, in accordance with μCT results. Furthermore, while TiN coatings promoted only primary bone regeneration, (Ti,Mg)N led to secondary bone regeneration in 6 weeks. These results indicated that Mg presence in the coatings accelerated bone regeneration in the fracture site. (Ti,Mg)N coating can be used as a practical method to increase the efficiency of existing bone fixation devices of varying geometry.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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