Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain.

Autor: Tu Y; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Fu Z; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA., Mao C; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Department of Medical Imaging, Second Affiliated Hospital of Xi'An Jiao Tong University, Xi'an, Shaan'Xi, China., Falahpour M; Center for Functional MRI, University of California San Diego, La Jolla, CA, USA., Gollub RL; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Park J; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Wilson G; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Napadow V; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Gerber J; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Chan ST; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Edwards RR; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kaptchuk TJ; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Liu T; Center for Functional MRI, University of California San Diego, La Jolla, CA, USA., Calhoun V; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA., Rosen B; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Kong J; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. kongj@nmr.mgh.harvard.edu.; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. kongj@nmr.mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Aug 07; Vol. 11 (1), pp. 3948. Date of Electronic Publication: 2020 Aug 07.
DOI: 10.1038/s41467-020-17788-z
Abstrakt: Thalamocortical dysrhythmia is a key pathology of chronic neuropathic pain, but few studies have investigated thalamocortical networks in chronic low back pain (cLBP) given its non-specific etiology and complexity. Using fMRI, we propose an analytical pipeline to identify abnormal thalamocortical network dynamics in cLBP patients and validate the findings in two independent cohorts. We first identify two reoccurring dynamic connectivity states and their associations with chronic and temporary pain. Further analyses show that cLBP patients have abnormal connectivity between the ventral lateral/posterolateral nucleus (VL/VPL) and postcentral gyrus (PoCG) and between the dorsal/ventral medial nucleus and insula in the less frequent connectivity state, and temporary pain exacerbation alters connectivity between the VL/VPL and PoCG and the default mode network in the more frequent connectivity state. These results extend current findings on thalamocortical dysfunction and dysrhythmia in chronic pain and demonstrate that cLBP pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.
Databáze: MEDLINE