Dissociating Arithmetic Operations in the Parietal Cortex Using 1 Hz Repetitive Transcranial Magnetic Stimulation: The Importance of Strategy Use.

Autor: Fresnoza S; Institute of Psychology, University of Graz, Graz, Austria.; BioTechMed, Graz, Austria., Christova M; Otto Loewi Research Center, Physiology Section, Medical University of Graz, Graz, Austria.; Department of Physiotherapy, University of Applied Sciences FH-Joanneum Graz, Graz, Austria., Purgstaller S; Institute of Psychology, University of Graz, Graz, Austria., Jehna M; Department of Radiology, Medical University of Graz, Graz, Austria., Zaar K; Department of Neurosurgery, Medical University of Graz, Graz, Austria., Hoffermann M; Department of Neurosurgery, Medical University of Graz, Graz, Austria., Mahdy Ali K; Department of Neurosurgery, Medical University of Graz, Graz, Austria., Körner C; Institute of Psychology, University of Graz, Graz, Austria.; BioTechMed, Graz, Austria., Gallasch E; BioTechMed, Graz, Austria.; Otto Loewi Research Center, Physiology Section, Medical University of Graz, Graz, Austria., von Campe G; Department of Neurosurgery, Medical University of Graz, Graz, Austria., Ischebeck A; Institute of Psychology, University of Graz, Graz, Austria.; BioTechMed, Graz, Austria.
Jazyk: angličtina
Zdroj: Frontiers in human neuroscience [Front Hum Neurosci] 2020 Jul 16; Vol. 14, pp. 271. Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2020).
DOI: 10.3389/fnhum.2020.00271
Abstrakt: The triple-code model (TCM) of number processing suggests the involvement of distinct parietal cortex areas in arithmetic operations: the bilateral horizontal segment of the intraparietal sulcus (hIPS) for arithmetic operations that require the manipulation of numerical quantities (e.g., subtraction) and the left angular gyrus (AG) for arithmetic operations that require the retrieval of answers from long-term memory (e.g., multiplication). Although neuropsychological, neuroimaging, and brain stimulation studies suggest the dissociation of these operations into distinct parietal cortex areas, the role of strategy (online calculation vs. retrieval) is not yet fully established. In the present study, we further explored the causal involvement of the left AG for multiplication and left hIPS for subtraction using a neuronavigated repetitive transcranial magnetic stimulation (rTMS) paradigm. Stimulation sites were determined based on an fMRI experiment using the same tasks. To account for the effect of strategy, participants were asked whether they used retrieval or calculation for each individual problem. We predicted that the stimulation of the left AG would selectively disrupt the retrieval of the solution to multiplication problems. On the other hand, stimulation of the left hIPS should selectively disrupt subtraction. Our results revealed that left AG stimulation was detrimental to the retrieval and online calculation of solutions for multiplication problems, as well as, the retrieval (but not online calculation) of the solutions to subtraction problems. In contrast, left hIPS stimulation had no detrimental effect on both operations regardless of strategy.
(Copyright © 2020 Fresnoza, Christova, Purgstaller, Jehna, Zaar, Hoffermann, Mahdy Ali, Körner, Gallasch, von Campe and Ischebeck.)
Databáze: MEDLINE