A craniopharyngioma in a Wistar rat most likely originated in a Rathke's cleft cyst.
| Autor: | Polledo L; AnaPath GmbH, AnaPath Services, Hammerstrasse 49, 4410 Liestal, Switzerland., Kreutzer R; AnaPath GmbH, AnaPath Services, Hammerstrasse 49, 4410 Liestal, Switzerland., Okazaki Y; AnaPath GmbH, AnaPath Services, Hammerstrasse 49, 4410 Liestal, Switzerland., Razinger T; AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland., Weber K; AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of toxicologic pathology [J Toxicol Pathol] 2020 Jul; Vol. 33 (3), pp. 183-187. Date of Electronic Publication: 2020 Apr 03. |
| DOI: | 10.1293/tox.2019-0068 |
| Abstrakt: | We examined a 110-week-old RccHan TM : WIST Wistar male rat from a carcinogenicity study. No clinical signs were observed, and the rat was sacrificed at the end of the study. Macroscopically, within the midline of the sphenoid bone, was a 10 mm, non-infiltrative, soft, heterogeneous mass. Microscopic evaluation showed an expansile, cystic proliferation, consisting of two patterns of epithelial lining: well-differentiated areas lined by a single layer to a pseudostratified, ciliated-cuboidal epithelia with Goblet cells compatible with Rathke's cleft cyst; and poorly differentiated ones that formed irregular papillary projections, covered by atypical epithelia with squamous differentiation and hyperkeratosis compatible with areas of craniopharyngioma. Pleomorphisms were high in atypical areas with up to 2-3 mitotic figures per high power field. Within the cystic cavities, there was abrupt keratinization, mucus, cholesterol clefts, and foci of foamy macrophages. Immunohistochemistry revealed strong pancytokeratin immunolabelling of neoplastic cells confirming the epithelial origin. Well-differentiated epithelial lining showed cytokeratin-20 and cytokeratin-8 immunoreactivity, whereas the atypical squamous epithelium presented with a loss of cytokeratin-20 positive signal and weak to moderate positivity with cytokeratin-8. Areas compatible with a Rathke's cleft cyst and craniopharyngioma were considered to co-exist in the same mass. Competing Interests: The authors declare no conflicts of interest. The author(s) received no financial support for the research, authorship, and/or publication of this article. (©2020 The Japanese Society of Toxicologic Pathology.) |
| Databáze: | MEDLINE |
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