Marijuana use and pneumonia risk in a cohort of HIV-infected and HIV-uninfected men.

Autor: Quint JJ; Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA. Electronic address: jquint@ucla.edu., Tashkin DP; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA., McKay HS; Department of Epidemiology, Johns Hopkins University, Baltimore, MD., Plankey MW; Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington, DC., Stosor V; Feinberg School of Medicine, Northwestern University, Chicago, IL., Friedman MR; School of Public Health, University of Pittsburgh, Pittsburgh, PA., Detels R; Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA.
Jazyk: angličtina
Zdroj: Annals of epidemiology [Ann Epidemiol] 2020 Dec; Vol. 52, pp. 64-70.e2. Date of Electronic Publication: 2020 Aug 05.
DOI: 10.1016/j.annepidem.2020.07.018
Abstrakt: Background: The prevalence of marijuana use is increasing in the United States. Marijuana smoking has been shown to impair the microbicidal activity of alveolar macrophages and decrease the number of ciliated epithelial cells in the bronchi with a parallel increase in the number of mucus-secreting surface epithelial cells, which may increase the risk of pneumonia. However, it remains unclear whether there is an association between smoking marijuana and pneumonia.
Methods: Using data from the Multicenter AIDS Cohort Study (MACS), a long-term observational cohort study of men who have sex with men in the United States, we used Cox proportional hazards models to estimate the risk of pneumonia among HIV-infected (n = 2784) and HIV-uninfected (n = 2665) men from 1984 to 2013, adjusted for time-varying and fixed baseline covariates.
Results: Weekly or daily marijuana use was not significantly associated with increased risk of pneumonia among HIV-uninfected men (adjusted hazard ratio; 95% confidence limits: 0.83, 0.56-1.23). In the disaggregated dose-response analysis, daily use (0.68, 0.34-1.35) was associated with a lower point estimate than weekly use [0.99, 0.79-1.25].
Conclusion: Marijuana smoking was not associated with a significant increase in risk of pneumonia among HIV-infected or HIV-uninfected men.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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