[Characteristics of the metabolic status of children of the first year of life with protein-energy deficiency depending on the gestational age at birth.]

Autor:	Gorbacheva IV; Samara State Medical University, 443099, Samara, Russia., Kuznetsova OU; Samara State Medical University, 443099, Samara, Russia., Gilmiyarova FN; Samara State Medical University, 443099, Samara, Russia., Pechkurov DV; Samara State Medical University, 443099, Samara, Russia., Vinogradova LN; Samara State Medical University, 443099, Samara, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2020 Jun 04; Vol. 65 (7), pp. 405-410.
DOI:	10.18821/0869-2084-2020-65-7-405-410
Abstrakt:	Comparative analysis of energy-plastic exchange indicators in mature and premature children of the first year of life in the development of protein-energy malnutrition (PEM) was carried out. Unidirectional changes are revealed, including an increase in creatinine, lactate and creatine phosphokinase activity levels, suggesting a n increasing muscle mass deficit against the background of glucose anaerobic oxidation activation. In preterm infants, glucose and triacylglicerine levels decrease, which reflects uncompensated insufficiency of energy substrates and, accordingly, ATP level. Multidirectional deviations in metabolism are pyruvate and ATP content: increase in full-term infants and decrease in preterm infants, that should be taken into account when monitoring condition of children with PEM. A significant decrease of pyruvic acid in preterm infants against the background of the levels of total protein, albumin, hemoglobin, and transferrin, not exceeding reference values, can obviously testify to the active use of this integral metabolite to maintain the fund of substituted amino acids. Development of this pathology in both mature and premature infants creates a pre-morbid background for iron deficiency anemia-diagnostic panel, which should be supplemented by calculation of transferrin saturation coefficient. Regardless of gestational age in childbirth during the formation of PEM, the lipid spectrum is rearranged according to atherogenic type: at normal values of total cholesterol, there is a significant increase in low and very low density lipoproteins with an increase in the atherogenicity coefficient. This singles out children with the pathology in question as a risk group for the development of the atherosclerotic process later, which justifies the recommendation to control the lipid profile in children of the first year of life. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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