Essential oil spray reduces clinical signs of insect bite hypersensitivity in horses.

Autor: Cox A; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia., Wood K; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.; School of Integrative Biology, University of Liverpool, Bishoftu, Ethiopia., Coleman G; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia., Stewart AJ; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia., Bertin FR; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia., Owen H; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.; Vetnostics, QML Pathology, Mansfield, Queensland, Australia., Suen WW; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.; CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia., Medina-Torres CE; School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
Jazyk: angličtina
Zdroj: Australian veterinary journal [Aust Vet J] 2020 Aug; Vol. 98 (8), pp. 411-416. Date of Electronic Publication: 2020 Aug 06.
DOI: 10.1111/avj.12963
Abstrakt: Objective: To assess the efficacy of an herbal spray combining various essential oils, with a claim of mast cell stabilisation, antipruritic, anti-inflammatory, and insect repellent effects on the clinical presentation of insect bite hypersensitivity (IBH) in horses.
Design: Double-blinded, placebo-controlled, randomised, cross-over clinical trial.
Methods: Twenty adult horses with clinical IBH were treated with a daily application of herbal spray or placebo for 28 days in a randomised, cross-over fashion, separated by a>28-day washout period. Horses were examined and scored prior to and after the completion of each treatment. Histopathology was performed on four horses. Owners kept daily diaries of observations.
Results: The herbal spray significantly reduced the severity of all assessed parameters (pruritus, excoriations, lichenification and alopecia; P < 0.05) compared with baseline values (pretreatment) and with placebo. Owners reported improvement of pruritus in 19/20 horses (95%) with complete resolution in 17 horses (85%) following treatment. Skin biopsies showed resolution of orthokeratosis in 4/4 horses, reduced thickness of the stratum spinosum in 2/4 horses and complete resolution of histopathological abnormalities in 1/4 horses after treatment, compared with either no change or deterioration of histopathologic lesions after placebo. No side effects were observed.
Conclusions: The tested herbal spray may be an effective treatment for the management of equine IBH.
(© 2020 Australian Veterinary Association.)
Databáze: MEDLINE
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