Irinotecan and temozolomide chemotherapy in paediatric and adult populations with relapsed Ewing Sarcoma.

Autor: Salah S; King Hussein Cancer Centre, Amman, Jordan., To YH; Peter MacCallum Cancer Centre, Melbourne, Australia., Khozouz O; King Hussein Cancer Centre, Amman, Jordan., Ismail T; King Hussein Cancer Centre, Amman, Jordan., Yaser S; King Hussein Cancer Centre, Amman, Jordan., Alnsour A; King Hussein Cancer Centre, Amman, Jordan., Shahin O; King Hussein Cancer Centre, Amman, Jordan.; UT MD Anderson Cancer Centre, Huston, TX, USA., Sultan I; King Hussein Cancer Centre, Amman, Jordan., Abuhijlih R; King Hussein Cancer Centre, Amman, Jordan., Halalsheh H; King Hussein Cancer Centre, Amman, Jordan., Abuhijla F; King Hussein Cancer Centre, Amman, Jordan., Lewin J; Peter MacCallum Cancer Centre, Melbourne, Australia. jeremy.lewin@petermac.org.; ONTrac at Peter Mac Victorian Adolescent and Young Adult Cancer Service, Melbourne, Australia. jeremy.lewin@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia. jeremy.lewin@petermac.org.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2021 Apr; Vol. 23 (4), pp. 757-763. Date of Electronic Publication: 2020 Aug 05.
DOI: 10.1007/s12094-020-02466-9
Abstrakt: Background: Irinotecan and temozolomide (IT) is a widely used regimen for relapsed Ewing sarcoma (ES), although studies are largely limited to paediatric populations.
Methods: We retrospectively reviewed paediatric (< 18 years) and adult patients (≥ 18 years) treated with salvage IT at two institutions. Haematologic toxicities were graded according to common terminology criteria of adverse events. Survival was estimated by the Kaplan-Meier method and compared by the Log Rank test.
Results: Fifty-three patients were treated with IT from Jan, 2010 to Dec, 2018 (n = 16 paediatric; n = 37 adult). IT was given as second-line (n = 34; 64%) or ≥ third-line (n = 19; 36%). There was no difference in ≥ grade 3/4 haematologic toxicity between paediatrics and adults (31% vs. 35% respectively; p = 0.76). The frequency of diarrhoea of any grade was similar (38% in each group). Of 43 patients assessable for response, 12 (28%) had objective response (1 CR, 11 PR), 12 (28%) stable disease and 19 (44%) disease progression. Objective response rate did not differ between the two groups (36% in paediatrics vs. 25% in adults; p = 0.47). Median PFS was superior in paediatrics vs. adults (7.4 vs. 2.2 months, p = 0.039).
Conclusion: Irinotecan and temozolomide (IT) chemotherapy has activity for relapsed ES, with favourable toxicity and equally observed objective responses in the paediatric and adult populations. The observed superior PFS for the paediatric cohort requires further confirmation in future studies.
Databáze: MEDLINE
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