Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation.

Autor:	Pavo IJ; Department of Pediatrics, Medical University of Vienna, Vienna, Austria., Pavo N; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Kastner N; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Traxler D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Lukovic D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Zlabinger K; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Spannbauer A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Riesenhuber M; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Lorant D; Department of Anesthesiology, Medical University of Vienna, Vienna, Austria., Bartko PE; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Goliasch G; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Hülsmann M; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Winkler J; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Gyöngyösi M; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Jazyk:	angličtina
Zdroj:	JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Jul 27; Vol. 5 (7), pp. 715-726. Date of Electronic Publication: 2020 Jul 27 (Print Publication: 2020).
DOI:	10.1016/j.jacbts.2020.05.011
Abstrakt:	Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2) NEP seems to be downregulated under HF conditions; and 3) that the value of plasma NEP concentrations and activity as biomarkers is questionable. For the first time, these data provide basic knowledge on HF-related pathophysiological alterations of the NEP system and contribute to understanding the mechanism of action of angiotensin-receptor neprilysin-inhibitors, which remains elusive despite broad clinical applications. (© 2020 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu