Development of Comprehensible Prescription Label Instructions: A Study Protocol for a Mixed-Methods Approach.

Autor:	Maghroudi E; Department of Patient Information, Health Base Foundation, Houten, Netherlands.; Department of Family Medicine, Research School CAPHRI, Maastricht University, Maastricht, Netherlands., van Hooijdonk CMJ; Department of Languages, Literature & Communication, Faculty of Humanities, Universiteit Utrecht, Utrecht, Netherlands., van Dijk L; Department of Pharmaceutical Care, Nivel, Netherlands Institute for Health Services Research, Utrecht, Netherlands.; Department of PharmacoTherapy, Epidemiology & Economics (PTEE), Faculty of Mathematics and Natural Sciences, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands., Boland G; Department of Prevention and Care for the Chronically Ill Programme, Pharos, Dutch Centre of Expertise on Health Disparities, Utrecht, Netherlands., de Haas C; Department of Patient Information, Health Base Foundation, Houten, Netherlands., Journée-Gilissen M; Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands., van der Velden J; Department of Prevention and Care for the Chronically Ill Programme, Pharos, Dutch Centre of Expertise on Health Disparities, Utrecht, Netherlands., Vervloet M; Department of Pharmaceutical Care, Nivel, Netherlands Institute for Health Services Research, Utrecht, Netherlands., Westerhof H; Department of Computerization of General Practitioner Care, NHG, The Dutch College of General Practitioners, Utrecht, Netherlands., Rademakers JJDJM; Department of Family Medicine, Research School CAPHRI, Maastricht University, Maastricht, Netherlands.; Department of Pharmaceutical Care, Nivel, Netherlands Institute for Health Services Research, Utrecht, Netherlands., Borgsteede SD; Department of Clinical Decision Support, Health Base Foundation, Houten, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2020 Jul 15; Vol. 11, pp. 981. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).
DOI:	10.3389/fphar.2020.00981
Abstrakt:	Introduction: Patients receive information about their medication from different sources, including prescription labels. These labels are physically attached to each package dispensed to patients and contain the most important instructions on how to use the medication correctly. However, many patients experience difficulties in understanding and applying the instructions on these labels correctly, especially patients with limited health literacy. The aim of this study is to investigate the comprehensibility of prescription label instructions among patients with adequate and limited health literacy skills, and to implement improvements in primary health care. Methods: We used a mixed-methods approach, which consisted of four phases. Phase 1 (desk research) was divided into a systematic literature review on the comprehensibility of prescription label instructions (1a) and a content analysis of the textual elements in Dutch prescription label instructions (1b). In phase 2 (patient studies), semi-structured interviews were conducted to investigate the comprehensibility of seven prescription labels among patients with different health literacy skills (2a), and a quantitative study in which the comprehensibility of six optimized prescription labels was compared among patients with different health literacy skills (2b). Patient studies were conducted in eight Dutch pharmacies. In phase 3 optimized prescription label instructions were implemented in national medication databases which has been supported by a guideline (3a), and education of pharmacy workers (3b). Phase 4 consists of evaluating the optimized prescription label instructions by experiences from patients and pharmacists. Anticipated Results: This mixed-methods approach will result in scientific publications of the individual studies, and a guideline on how to compose comprehensible prescription label instructions to be put on medication packages. Optimized prescription label instructions will be implemented in national medication databases. Discussion: This protocol describes a mixed-method research to compose and implement comprehensible prescription label instructions and will lead to knowledge about the comprehensibility of textual elements in these labels, with specific attention for patients with limited health literacy. Implementation of optimized prescription label instructions will lead to a better understanding of them, which may contribute to improved medication adherence. A limitation is that non-textual aspects of prescription labels are not investigated. (Copyright © 2020 Maghroudi, van Hooijdonk, van Dijk, Boland, de Haas, Journée-Gilissen, van der Velden, Vervloet, Westerhof, Rademakers and Borgsteede.)
Databáze:	MEDLINE
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