Farnesyl glycosides and one new triterpenoid saponin from the roots of Lecaniodiscus cupanioides Planch. ex Benth.

Autor: Messi LM; Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon; Institut de Recherche Agricole pour le Développement (IRAD), BP 2067, Yaoundé, Cameroon; UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France. Electronic address: linmarcellinmessi@yahoo.fr., Noté OP; Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon., Mbing JN; Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon., Vansteelandt M; UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France., Lavedan P; Institut de Chimie de Toulouse, UPS, France., Vedrenne M; Institut de Chimie de Toulouse, UPS, France., Pegnyemb DE; Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon., Haddad M; UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France. Electronic address: mohamed.haddad@ird.fr.
Jazyk: angličtina
Zdroj: Carbohydrate research [Carbohydr Res] 2020 Sep; Vol. 495, pp. 108092. Date of Electronic Publication: 2020 Jul 18.
DOI: 10.1016/j.carres.2020.108092
Abstrakt: Chemical investigation of the methanol extract of the roots of Lecaniodiscus cupanioides led to the isolation and characterisation of three new sesquiterpene glycosides, named cupanioidesosides A (1), B (2) and C (3), together with one new triterpenoid saponin named lecanioside A (4), Their structures were established by extensive analysis of spectroscopic methods including 1D and 2D NMR techniques (COSY, NOESY, TOCSY, HSQC, and HMBC) and HRESIMS. The four new compounds were evaluated for their antiproliferative activity against the Caco-2 cell line (human epithelial cell line). None of the isolated compounds showed positive activity in our assay. Our findings represent a valuable contribution to the chemotaxonomy Lecaniodiscus genus of the subfamily of Sapindoideae of Sapindaceae family, known to be a rich source of farnesol glycosides.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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