| Autor: |
Pontoriero F; St. Christopher's Hospital for Children-Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania., Silverman AM; St. Christopher's Hospital for Children-Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania., Pascasio JM; St. Christopher's Hospital for Children-Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania., Bajaj R; St. Christopher's Hospital for Children-Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania. |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2020 Nov-Dec; Vol. 23 (6), pp. 448-452. Date of Electronic Publication: 2020 Aug 05. |
| DOI: |
10.1177/1093526620945861 |
| Abstrakt: |
Carcinoma originating from the surface epithelium of the nasopharynx is classified by the World Health Organization (WHO) as nasopharyngeal carcinoma (NPC) and has 3 main types: keratinizing squamous cell carcinoma (WHO type 1) and nonkeratinizing carcinoma, differentiated (WHO type II), and undifferentiated (WHO type III). Nonkeratinizing NPC is strongly associated with prior Epstein-Barr virus (EBV) infection. These tumors may be divided into differentiated and undifferentiated carcinoma. Histologically, the tumor is characterized by syncytia of large malignant cells with vesicular nuclei, conspicuous nucleoli, and easily observed mitotic figures. We report a case of a 14-year-old boy diagnosed with EBV and human papillomavirus (HPV)-positive NPC (WHO type 3) with cytogenetics showing the presence of mosaic trisomy 2. This case report brings to light a rare cytogenetic aberration to our knowledge only reported once before in the literature in a xenograft model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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