Prolonged Release of Anti-Retroviral Efavirenz From System Using ZIF-8 as Carrier.

Autor:	Tabosa AÉGA; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., Ferreira AS; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., da Silva NM; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., da Silva Nascimento DDS; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., de Moura Ferraz LR; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., Silva JYR; Laboratory Rare Earths BSTR, Fundamental Departament of Chemistry, Federal University of Pernambuco, Av. Jornalista Aníbal Fernandes, s/n - Cidade Universitária, 50740-560, Recife-PE, Brazil., Junior SA; Laboratory Rare Earths BSTR, Fundamental Departament of Chemistry, Federal University of Pernambuco, Av. Jornalista Aníbal Fernandes, s/n - Cidade Universitária, 50740-560, Recife-PE, Brazil., da Silva RMF; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil., Rolim LA; Central Analytical of Drugs, Medicines and Food, Federal University of Vale do São Francisco, Av. José de Sá Maniçoba, s/n, Centro, 56304-917, Petrolina-PE, Brazil., Rolim-Neto PJ; Laboratory of Medication Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife-PE, Brazil.
Jazyk:	angličtina
Zdroj:	Current HIV research [Curr HIV Res] 2020; Vol. 18 (6), pp. 396-404.
DOI:	10.2174/1570162X18666200804130734
Abstrakt:	Background: Acquired Immunodeficiency Syndrome (AIDS) is a major public health problem in the world. One of the highly effective drugs in anti-HIV therapy is efavirenz (EFZ), which is classified as Class II according to the Classification System of Biopharmaceuticals, presenting low solubility and high permeability, this being an obstacle related to the drug. Objective: This study aimed to obtain an innovative system based on EFZ and the Zeolitic Imidazolate Framework (ZIF-8) to use in the development of prolonged-release pharmaceutical forms that can circumvent this problem. Methods: The EFZ: ZIF-8 system was obtained by a selected ex-situ method due to its higher incorporation efficiency. Different characterization techniques corroborated the obtainment of the system, and drug release was analyzed by dissolution testing under sink conditions, the profiles being adjusted to some kinetic models. Results: At pH 1.2, the structure of ZIF-8 breaks down rapidly, releasing a large amount of drug within either 3h or short time. In the pH 4.5 and 6.8 medium, the EFZ release from the EFZ: ZIF-8 system obtained in ethanol was prolonged, releasing 95% of the drug in 24h at pH 4.5 and 75% medium at pH 6.8. Conclusion: It is evident that a promising pH-sensitive system was obtained using ZIF-8 as a novel carrier of EFZ intended for the alternative treatment of AIDS. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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