| Autor: |
Anna Genaro MS; 1Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil.; 2Clínica Médica e Reumatologia, Universidade de Cuiabá (UNIC), Cuiabá, Brazil., Marchi MS; 2Clínica Médica e Reumatologia, Universidade de Cuiabá (UNIC), Cuiabá, Brazil., Perin MY; 2Clínica Médica e Reumatologia, Universidade de Cuiabá (UNIC), Cuiabá, Brazil., Cossô IS; 2Clínica Médica e Reumatologia, Universidade de Cuiabá (UNIC), Cuiabá, Brazil., Dezengrini Slhessarenko R; 1Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2020 Nov; Vol. 103 (5), pp. 2077-2082. |
| DOI: |
10.4269/ajtmh.20-0066 |
| Abstrakt: |
Chikungunya virus (CHIKV) is a global emergent arthritogenic alphavirus transmitted by anthropophilic Stegomyia mosquitoes. Chikungunya fever may evolve to chronic arthralgia in 57-80% of infected patients. This study was developed to identify possibly fast, simple low-cost biomarkers to monitor chronic CHIKV-induced articular disease. Between 2017 and 2018, we analyzed clinical data of patients meeting the criteria established by standard protocols to define chronic chikungunya articular disease. Patients were classified according to the disease activity scores, inflammatory biomarkers (erythrocyte sedimentation rate [ESR], ferritin, and C-reactive protein [CRP] serum), positive rheumatoid factor, comorbidities, smoking, and previous use of corticosteroids determined before beginning therapy. Of 106 patients, 98 (92.5%) were women with mean age of 52 ± 13 years, 6.8 ± 4.4 months of illness duration at the first medical appointment, and 6.7 ± 4.5 affected joints. Mean ESR (26 ± 19), CRP (2.6 ± 3.6), and stratified ferritin (144 ± 115) levels were normal according to reference values. There was no significance in comparing the levels of inflammatory biomarkers and the additional variables analyzed in the presence of moderate chronic joint disease in the study population. However, we identified a negative correlation between disease activity measures and duration of disease at the first medical evaluation after initial infection ( P < 0.001), corroborating data observed in the literature. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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