| Autor: |
Figueiredo LP; 1Immunology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil.; 2Graduate Program in Health Science, Federal University of Bahia, Salvador, Brazil., Almeida LDC; 3Otorhinolaryngology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil., Magalhães A; 1Immunology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil., Arruda S; 4Gonçalo Moniz Institute, Fiocruz, Salvador, Brazil., Lessa MM; 1Immunology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil.; 2Graduate Program in Health Science, Federal University of Bahia, Salvador, Brazil.; 3Otorhinolaryngology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil., Carvalho EM; 1Immunology Department, Professor Edgar Santos University Hospital, Federal University of Bahia, Salvador, Brazil.; 4Gonçalo Moniz Institute, Fiocruz, Salvador, Brazil. |
| Abstrakt: |
Mucosal leishmaniasis (ML) affects predominantly the nose and occurs usually weeks or months after the cure of the primary cutaneous lesion. The pathology of ML is characterized by an exaggerated inflammatory reaction with infiltration of lymphocytes, macrophages, and plasma cells. There is also a paucity of parasites and a strong delayed-type hypersensitivity reaction. Herein, we report a case of a young man who had a large ulcer in his left leg and complained of dysphagia. In nasofibrolaryngoscopy, there were nodular lesions in the oropharynx and rhinopharynx. The skin lesion biopsy showed a chronic inflammation with amastigotes inside macrophages, and DNA of Leishmania braziliensis confirmed the diagnosis of ML in tissue biopsied from the pharynx. The leishmaniasis skin test was negative. Cytokine evaluation showed lack of production of interferon (IFN)-γ, interleukin (IL)-1β, and IL-17 with enhancement of these cytokine levels after cure. |
