Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal.

Autor: Daniels RF; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute, Cambridge, MA, USA., Schaffner SF; Broad Institute, Cambridge, MA, USA., Dieye Y; PATH MACEPA, Seattle, WA, USA., Dieng G; PATH MACEPA, Seattle, WA, USA., Hainsworth M; PATH MACEPA, Seattle, WA, USA., Fall FB; Senegal National Malaria Control Programme, Dakar, Senegal., Diouf CN; District Medical Office, Richard Toll District, Richard Toll, Senegal., Ndiop M; Senegal National Malaria Control Programme, Dakar, Senegal., Cisse M; Senegal National Malaria Control Programme, Dakar, Senegal., Gueye AB; Senegal National Malaria Control Programme, Dakar, Senegal., Sarr O; Senegal National Malaria Control Programme, Dakar, Senegal., Guinot P; PATH MACEPA, Seattle, WA, USA., Deme AB; Dantec Teaching and Research Hospital, Dakar, Senegal., Bei AK; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Sy M; Dantec Teaching and Research Hospital, Dakar, Senegal., Thwing J; Centers for Disease Control and Prevention, Atlanta, GA, USA., MacInnis B; Broad Institute, Cambridge, MA, USA., Earle D; PATH MACEPA, Seattle, WA, USA., Guinovart C; Harvard University, Cambridge, MA, USA., Sene D; Senegal National Malaria Control Programme, Dakar, Senegal., Hartl DL; Harvard University, Cambridge, MA, USA., Ndiaye D; Cheikh Anta Diop University, Dakar, Senegal., Steketee RW; PATH MACEPA, Seattle, WA, USA., Wirth DF; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute, Cambridge, MA, USA., Volkman SK; Harvard T.H. Chan School of Public Health, Boston, MA, USA. svolkman@hsph.harvard.com.; Broad Institute, Cambridge, MA, USA. svolkman@hsph.harvard.com.; Simmons University, Boston, MA, USA. svolkman@hsph.harvard.com.
Jazyk: angličtina
Zdroj: Malaria journal [Malar J] 2020 Aug 03; Vol. 19 (1), pp. 276. Date of Electronic Publication: 2020 Aug 03.
DOI: 10.1186/s12936-020-03346-x
Abstrakt: Background: Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.
Methods: A genetic strategy was applied to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal.
Results: Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travellers compared to travellers.
Conclusions: These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje