Hearing loss and microstructural integrity of the brain in a dementia-free older population.

Autor:	Croll PH; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Reid RI; Department of Information Technology, Mayo Clinic Foundation, Rochester, Minnesota, USA., Goedegebure A; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Power MC; Department of Epidemiology, George Washington University Milken Institute School of Public Health, Washington, District of Columbia, USA., Rigters SC; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Sharrett AR; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA., de Jong RJB; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Mosley TH; The MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA., de Groot M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands., Lin FR; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Deal JA; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Nov; Vol. 16 (11), pp. 1515-1523. Date of Electronic Publication: 2020 Aug 02.
DOI:	10.1002/alz.12151
Abstrakt:	Introduction: As hearing loss has been identified as an important risk factor for dementia, we aimed to assess the association between hearing loss and microstructural integrity of the brain. Methods: A total of 1086 dementia-free participants (mean age = 75.2 [standard deviation: 4.9], 61.4% female) of the population-based Atherosclerosis Risk in Communities (ARIC) study underwent hearing assessment (2016-2017) and magnetic resonance imaging of the brain (2011-2013). Microstructural integrity was determined with diffusion tensor imaging. Multivariable linear regression was used to investigate associations between hearing loss and microstructural integrity of different brain regions and white matter (WM) tracts. Results: Hearing loss was associated with lower WM microstructural integrity in the temporal lobe, lower gray matter integrity of the hippocampus, and with lower WM microstructural integrity of the limbic tracts and the uncinate fasciculus. Conclusion: Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes. (© 2020 the Alzheimer's Association.)
Databáze:	MEDLINE
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