| Autor: |
Kamei T; Faculty of Pharmaceutical Sciences, Josai International University., Takahashi T; Faculty of Pharmaceutical Sciences, Josai International University., Teramae H; Faculty of Science, Josai University., Koyanagi J; Faculty of Pharmaceutical Sciences, Josai International University. |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2020; Vol. 68 (8), pp. 818-821. |
| DOI: |
10.1248/cpb.c20-00307 |
| Abstrakt: |
1-Fluoroindan-1-carboxyic acid (FICA) derivatives containing a monosubstituted benzene ring (1b-e) were synthesized as their methyl esters and their potential as chiral derivatizing agents (CDAs) were assessed by both 19 F- and 1 H-NMR spectroscopy. Introduction of a substituent at the 4-position in the benzene ring caused a 1.2-2 fold increase in Δδ F values when compared with that of FICA. This increase was investigated using a correlation model for 19 F-NMR and by the order of the stability of the synperiplanar (sp) and antiperiplanar (ap) conformers of the (R,S) and (S,S) diastereomers from the Gibbs' free energy at 298.15 K. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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