Outcome measures from experimental traumatic brain injury in male rats vary with the complete temporal biomechanical profile of the injury event.

Autor: Abdul-Wahab R; Center for Injury Biomechanics, Materials and Medicine, Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.; Department of Neurological Surgery, University of California, Davis, CA, USA., Long MT; Center for Injury Biomechanics, Materials and Medicine, Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA., Ordaz R; Department of Neurological Surgery, University of California, Davis, CA, USA., Lyeth BG; Department of Neurological Surgery, University of California, Davis, CA, USA., Pfister BJ; Center for Injury Biomechanics, Materials and Medicine, Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2020 Oct; Vol. 98 (10), pp. 2027-2044. Date of Electronic Publication: 2020 Aug 02.
DOI: 10.1002/jnr.24670
Abstrakt: Millions suffer a traumatic brain injury (TBI) each year wherein the outcomes associated with injury can vary greatly between individuals. This study postulates that variations in each biomechanical parameter of a head trauma lead to differences in histological and behavioral outcome measures that should be considered collectively in assessing injury. While trauma severity typically scales with the magnitude of injury, much less is known about the effects of rate and duration of the mechanical insult. In this study, a newly developed voice-coil fluid percussion injury system was used to investigate the effects of injury rate and fluid percussion impulse on a collection of post-injury outcomes in male rats. Collectively the data suggest a potential shift in the specificity and progression of neuronal injury and function rather than a general scaling of injury severity. While a faster, shorter fluid percussion first presents as a mild TBI, neuronal loss and some behavioral tasks were similar among the slower and faster fluid percussion injuries. This study concludes that the sequelae of neuronal degeneration and behavioral outcomes are related to the complete temporal profile of the fluid percussion and do not scale only with peak pressure.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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