Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children.

Autor: Stratakis N; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Complex Genetics and Epidemiology, CAPHRI School for Public Health and Primary Care, University of Maastricht, Maastricht, the Netherlands., V Conti D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Jin R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Margetaki K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Valvi D; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY., Siskos AP; Department of Surgery & Cancer and Department of Metabolism, Digestion & Reproduction, Imperial College London, London, United Kingdom., Maitre L; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Garcia E; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Varo N; Laboratory of Biochemistry, University Clinic of Navarra, Pamplona, Spain., Zhao Y; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Roumeliotaki T; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Vafeiadi M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Urquiza J; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Fernández-Barrés S; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Heude B; Center of Research in Epidemiology and Statistics, INSERM, INRAe, University of Paris, Paris, France., Basagana X; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Casas M; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Fossati S; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Gražulevičienė R; Department of Environmental Sciences, Vytauto Didžiojo Universitetas, Kaunas, Lithuania., Andrušaitytė S; Department of Environmental Sciences, Vytauto Didžiojo Universitetas, Kaunas, Lithuania., Uppal K; Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, Emory University, Atlanta, GA., McEachan RRC; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom., Papadopoulou E; Norwegian Institute of Public Health, Oslo, Norway., Robinson O; MRC Centre for Environment and Health, Imperial College London, London, United Kingdom., Haug LS; Norwegian Institute of Public Health, Oslo, Norway., Wright J; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom., Vos MB; Department of Pediatrics, School of Medicine and Nutrition Health Sciences, Emory University, Atlanta, GA.; Children's Healthcare of Atlanta, Atlanta, GA., Keun HC; Department of Surgery & Cancer and Department of Metabolism, Digestion & Reproduction, Imperial College London, London, United Kingdom., Vrijheid M; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Madrid, Spain., Berhane KT; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., McConnell R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Chatzi L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Complex Genetics and Epidemiology, CAPHRI School for Public Health and Primary Care, University of Maastricht, Maastricht, the Netherlands.
Jazyk: angličtina
Zdroj: Hepatology (Baltimore, Md.) [Hepatology] 2020 Nov; Vol. 72 (5), pp. 1758-1770. Date of Electronic Publication: 2020 Oct 19.
DOI: 10.1002/hep.31483
Abstrakt: Background and Aims: Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children.
Approach and Results: We used data from 1,105 mothers and their children (median age, 8.2 years; interquartile range, 6.6-9.1) from the European Human Early-Life Exposome cohort (consisting of six existing population-based birth cohorts in France, Greece, Lithuania, Norway, Spain, and the United Kingdom). We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluorononanoate, perfluorohexane sulfonate, and perfluoroundecanoate in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase in child serum. Using Bayesian kernel machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confidence interval, 1.21-1.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branched-chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine [PC] aa C36:1 and Lyso-PC a C18:1).
Conclusions: Developmental exposure to PFAS can contribute to pediatric liver injury.
(© 2020 by the American Association for the Study of Liver Diseases.)
Databáze: MEDLINE