Hyperventilation Increases the Randomness of Ocular Palatal Tremor Waveforms.

Autor: Theeranaew W; Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Department of Neurology, University Hospitals, Cleveland, OH, USA.; Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, USA., Kim HJ; Research Administration Team, Seoul National University Bundang Hospital, Seongnam, South Korea., Loparo K; Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, USA., Kim JS; Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea.; Department of Neurology, Dizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, South Korea., Shaikh AG; Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. aasefshaikh@gmail.com.; Department of Neurology, University Hospitals, Cleveland, OH, USA. aasefshaikh@gmail.com.; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA. aasefshaikh@gmail.com.; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. aasefshaikh@gmail.com.; Department of Neurology, 11100 Euclid Avenue, Cleveland, OH, 44110, USA. aasefshaikh@gmail.com.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2021 Oct; Vol. 20 (5), pp. 780-787.
DOI: 10.1007/s12311-020-01171-1
Abstrakt: Hyperventilation changes the extracellular pH modulating many central pathologies, such as tremor. The questions that remain unanswered are the following: (1) Hyperventilation modulates which aspects of the oscillations? (2) Whether the effects of hyperventilation are instantaneous and the recovery is rapid and complete? Here we study the effects of hyperventilation on eye oscillations in the syndrome of oculopalatal tremor (OPT), a disease model affecting the inferior olive and cerebellar system. These regions are commonly involved in the pathogenesis of many movement disorders. The focus on the ocular motor system also allows access to the well-known physiology and precise measurement techniques. We found that hyperventilation causes modest but insignificant changes in the intensity of oscillation displacement (i.e., how large the eye excursions are) and velocity (i.e., how fast do the eyes move during oscillations). We found the robust increase in the randomness of the oscillatory waveform during hyperventilation and it instantaneously reverts to the baseline after hyperventilation. The subsequent analysis classified the oscillations according to their waveform shape and randomness into different clusters. The hyperventilation substantially changed the cluster type in 60% of the subjects, but it reverted to the pre-hyperventilation cluster at the conclusion of the hyperventilation. In summary, hyperventilation instantaneously affects the randomness of the oscillatory waveforms but there are less substantial effects on the intensity. The deficits reverse immediately at the end of the hyperventilation.
(© 2020. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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