Outcomes of Maternal-Newborn Dyads After Maternal SARS-CoV-2.

Autor:	Verma S; Departments of Pediatrics and sourabh.verma@nyulangone.org.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Bradshaw C; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Auyeung NSF; Departments of Pediatrics and., Lumba R; Departments of Pediatrics and., Farkas JS; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Sweeney NB; Department of Pediatrics, New York University Long Island School of Medicine, New York University, New York, New York; and., Wachtel EV; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Bailey SM; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Noor A; Department of Pediatrics, New York University Long Island School of Medicine, New York University, New York, New York; and., Kunjumon B; Departments of Pediatrics and., Cicalese E; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Hate R; Departments of Pediatrics and., Lighter JL; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Alessi S; Departments of Pediatrics and., Schweizer WE; Obstetrics and Gynecology, and., Hanna N; Department of Pediatrics, New York University Long Island School of Medicine, New York University, New York, New York; and., Roman AS; Division of Maternal Fetal Medicine, New York University Grossman School of Medicine, New York, New York., Dreyer B; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York., Mally PV; Departments of Pediatrics and.; Department of Pediatrics, Bellevue Hospital Center, New York, New York.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2020 Oct; Vol. 146 (4). Date of Electronic Publication: 2020 Jul 31.
DOI:	10.1542/peds.2020-005637
Abstrakt:	Background and Objectives: Infection with a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. There are limited data describing the impact of SARS-CoV-2 infection on pregnant mothers and their newborns. The objective of this study is to describe characteristics and outcomes of maternal-newborn dyads with confirmed maternal SARS-CoV-2. Methods: This was a multicenter, observational, descriptive cohort study with data collection from charts of maternal-newborn dyads who delivered at 4 major New York City metropolitan area hospitals between March 1 and May 10, 2020, with maternal SARS-CoV-2 infection. Results: There were a total of 149 mothers with SARS-CoV-2 infection and 149 newborns analyzed (3 sets of twins; 3 stillbirths). Forty percent of these mothers were asymptomatic. Approximately 15% of symptomatic mothers required some form of respiratory support, and 8% required intubation. Eighteen newborns (12%) were admitted to the ICU. Fifteen (10%) were born preterm, and 5 (3%) required mechanical ventilation. Symptomatic mothers had more premature deliveries (16% vs 3%, P = .02), and their newborns were more likely to require intensive care (19% vs 2%, P = .001) than asymptomatic mothers. One newborn tested positive for SARS-CoV-2, which was considered a case of horizontal postnatal transmission. Conclusions: Although there was no distinct evidence of vertical transmission from mothers with SARS-CoV-2 to their newborns, we did observe perinatal morbidities among both mothers and newborns. Symptomatic mothers were more likely to experience premature delivery and their newborns to require intensive care. Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. (Copyright © 2020 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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