Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals.

Autor: Wozniak KL; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Bainbridge RE; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Summerville DW; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Tembo M; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Phelps WA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Sauer ML; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Wisner BW; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Czekalski ME; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Pasumarthy S; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Hanson ML; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Linderman MB; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Luu CH; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Boehm ME; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Sanders SM; Department of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, and Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, United States of America., Buckley KM; Department of Biological Sciences, Auburn University, Auburn, Alabama, United States of America., Bain DJ; Department of Geology and Environmental Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Nicotra ML; Department of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, and Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, United States of America., Lee MT; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Carlson AE; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Jazyk: angličtina
Zdroj: PLoS biology [PLoS Biol] 2020 Jul 31; Vol. 18 (7), pp. e3000811. Date of Electronic Publication: 2020 Jul 31 (Print Publication: 2020).
DOI: 10.1371/journal.pbio.3000811
Abstrakt: One of the earliest and most prevalent barriers to successful reproduction is polyspermy, or fertilization of an egg by multiple sperm. To prevent these supernumerary fertilizations, eggs have evolved multiple mechanisms. It has recently been proposed that zinc released by mammalian eggs at fertilization may block additional sperm from entering. Here, we demonstrate that eggs from amphibia and teleost fish also release zinc. Using Xenopus laevis as a model, we document that zinc reversibly blocks fertilization. Finally, we demonstrate that extracellular zinc similarly disrupts early embryonic development in eggs from diverse phyla, including Cnidaria, Echinodermata, and Chordata. Our study reveals that a fundamental strategy protecting human eggs from fertilization by multiple sperm may have evolved more than 650 million years ago.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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