Antimicrobial resistance of Pasteurella multocida isolates recovered from swine pneumonia in Spain throughout 2017 and 2018.

Autor: Petrocchi-Rilo M; Department of Animal Health, Faculty of Veterinary Medicine, University of León, Spain., Gutiérrez-Martín CB; Department of Animal Health, Faculty of Veterinary Medicine, University of León, Spain., Méndez-Hernández JI; Department of Animal Health, Faculty of Veterinary Medicine, University of León, Spain., Rodríguez-Ferri EF; Department of Animal Health, Faculty of Veterinary Medicine, University of León, Spain., Martínez-Martínez S; Department of Animal Health, Faculty of Veterinary Medicine, University of León, Spain.
Jazyk: angličtina
Zdroj: Veterinary and animal science [Vet Anim Sci] 2018 Dec 12; Vol. 7, pp. 100044. Date of Electronic Publication: 2018 Dec 12 (Print Publication: 2019).
DOI: 10.1016/j.vas.2018.100044
Abstrakt: A total of 32 Pasteurella multocida isolates were obtained from 60 cases of swine pneumonic lungs collected in "Castilla y León" (northwestern Spain) between November 2017 and April 2018. Capsular type A isolates were isolated from 96.9% cases and capsular type D from the remaining 3.1%. All isolates were characterized for their susceptibilities to eight antimicrobial agents and the presence of eight resistance genes. The frequency of susceptibility was lower than 60% in four of the drugs, 84.4% of the isolates showed resistance to at least two compounds, and 46.9% to a combination of three drugs. The resistance patterns suggested that enrofloxacin, chloramphenicol, tetracycline and cefotaxime were the compounds most likely active to P. multocida . The usage of PCR revealed that erm C, bla ROB1 , tet B and msr E genes occurred in more than 37.0% isolates, that suggested its putative accountability in the resistance of the strains harbor them. However, most were detected in susceptible strains and only a genetic explanation for the resistance could be linked to erythromycin. Therefore, the resistances to clyndamicin, cotrimoxazol, β-lactams and tetracyclin observed by phenotypic testing remains genetically unexplained and further investigations are required.
(© 2018 The Authors.)
Databáze: MEDLINE