99mTc-sestamibi SPECT/CT and 18F-FDG-PET/CT have similar performance but different imaging patterns in newly diagnosed multiple myeloma.

Autor:	Mosci C; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences., Pericole FV; Hematology and Hemotherapy Center (Hemocentro), University of Campinas (UNICAMP)., Oliveira GB; Hematology and Hemotherapy Center (Hemocentro), University of Campinas (UNICAMP)., Delamain MT; Hematology and Hemotherapy Center (Hemocentro), University of Campinas (UNICAMP)., Takahashi MES; Gleb Wataghin Physics Institute.; Post-Graduation Program in Internal Medicine, School of Medical Sciences., Carvalheira JBC; Department of Internal Medicine, Division of Oncology, School of Medical Sciences., Etchebehere ECSC; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences., Santos AO; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences., Miranda ECM; Hematology and Hemotherapy Center (Hemocentro), University of Campinas (UNICAMP)., Lima MCL; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences., Amorim BJ; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences., de Souza CA; Hematology and Hemotherapy Center (Hemocentro), University of Campinas (UNICAMP).; Division of Hematology, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, Brazil., Lorand-Metze I; Division of Hematology, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, Brazil., Ramos CD; Department of Radiology, Division of Nuclear Medicine, School of Medical Sciences.; Post-Graduation Program in Internal Medicine, School of Medical Sciences.
Jazyk:	angličtina
Zdroj:	Nuclear medicine communications [Nucl Med Commun] 2020 Oct; Vol. 41 (10), pp. 1081-1088.
DOI:	10.1097/MNM.0000000000001259
Abstrakt:	Purpose: F-fluorodeoxiglucose (F-FDG)-PET/CT has been widely used to evaluate multiple myeloma. Tc-sestamibi (MIBI) scintigraphy has also been proposed for assessing multiple myeloma, but its use with state-of-the-art single-photon emission computed tomography/computed tomography (SPECT/CT) technology has not been fully evaluated.This study aimed to compare these two imaging modalities in multiple myeloma staging. Materials and Methods: Sixty-two patients with recently diagnosed multiple myeloma were submitted to whole-body F-FDG-PET/CT and whole-body MIBI scans plus SPECT/CT of the chest and abdomen/pelvis. Number of focal lesions, contiguous soft tissue involvement (CSTI), extramedullary lesions (EMLs) and diffuse bone marrow (BM) involvement were recorded. Results: PET/CT was positive in 59 patients (95%) and MIBI SPECT/CT in 58 (93%) (P = 0.69). MIBI detected more diffuse bone marrow involvement than PET/CT (respectively 78 vs. 58% of the patients), while PET/CT demonstrated more focal lesions than MIBI SPECT/CT (81 vs. 54% of the patients) (P = 0.002). PET/CT detected EMLs in four subjects and MIBI in one subject. CSTI was found in 28 (45%) and 23 (37%) patients on PET/CT and MIBI images, respectively (P = 0.36). Three patients with lytic lesions and no FDG uptake were MIBI positive, and two subjects with lytic lesions without MIBI uptake were FDG positive. Conclusion: MIBI SPECT/CT performs similarly to F-FDG-PET/CT in identifying sites of active disease in multiple myeloma staging. MIBI is more efficient than FDG for detecting the diffuse involvement of bone marrow but less efficient for detecting focal lesions. Some patients presented a 'mismatch' pattern of FDG/MIBI uptake.
Databáze:	MEDLINE
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