Human fetal microglia acquire homeostatic immune-sensing properties early in development.

Autor: Kracht L; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Borggrewe M; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Eskandar S; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.; Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Brouwer N; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Chuva de Sousa Lopes SM; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium., Laman JD; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Scherjon SA; Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Prins JR; Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Kooistra SM; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. s.m.kooistra@umcg.nl b.j.l.eggen@umcg.nl., Eggen BJL; Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. s.m.kooistra@umcg.nl b.j.l.eggen@umcg.nl.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2020 Jul 31; Vol. 369 (6503), pp. 530-537.
DOI: 10.1126/science.aba5906
Abstrakt: Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
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