How do cancer cells replenish their fuel supply?

Autor:	Alameddine AK; Division of Cardiac Surgery, Baystate Medical Center, Springfield, MA, USA., Conlin FT; Anesthesiology, Baystate Medical Center, Springfield, MA, USA.; University of Massachusetts Medical School, Boston, MA, USA., Binnall BJ; Division of Cardiac Surgery, Baystate Medical Center, Springfield, MA, USA., Alameddine YA; MassDerm associates, Beverly, MA, USA., Alameddine KO; Swedish Covenant Hospital, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2018 Jun; Vol. 1 (1), pp. e1003. Date of Electronic Publication: 2018 Apr 30.
DOI:	10.1002/cnr2.1003
Abstrakt:	Background: Multiple genetic changes, availability of cellular nutrients and metabolic alterations play a pivotal role in oncogenesis AIMS: We focus on cancer cell's metabolic properties, and we outline the cross talks between cellular oncogenic growth pathways in cancer metabolism. The review also provides a synopsis of the relevant cancer drugs targeting metabolic activities that are at various stages of clinical development. Methods: We review literature published within the last decade to include select articles that have highlighted energy metabolism crucial to the development of cancer phenotypes. Results: Cancer cells maintain their potent metabolism and keep a balanced redox status by enhancing glycolysis and autophagy and rerouting Krebs cycle intermediates and products of β-oxydation. Conclusions: The processes underlying cancer pathogenesis are extremely complex and remain elusive. The new field of systems biology provides a mathematical framework in which these homeostatic dysregulation principles may be examined for better understanding of cancer phenotypes. Knowledge of key players in cancer-related metabolic reprograming may pave the way for new therapeutic metabolism-targeted drugs and ultimately improve patient care. (© 2018 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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