Occupational cohort study of current and former workers exposed to chrysotile in mine and processing facilities in Asbest, the Russian Federation: Cohort profile of the Asbest Chrysotile Cohort study.

Autor: Schüz J; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Bukhtiyarov I; Federal State Budgetary Scientific Institution 'Izmerov Research Institute of Occupational Health' (IRIOH), Moscow, the Russian Federation.; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, the Russian Federation., Olsson A; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Moissonnier M; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Ostroumova E; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Feletto E; International Agency for Research on Cancer (IARC/WHO), Lyon, France.; Cancer Council New South Wales, Cancer Research Division, Woolloomooloo, Australia., Schonfeld SJ; International Agency for Research on Cancer (IARC/WHO), Lyon, France.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Byrnes G; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Tskhomariia I; Federal State Budgetary Scientific Institution 'Izmerov Research Institute of Occupational Health' (IRIOH), Moscow, the Russian Federation., McCormack V; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Straif K; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Kashanskiy S; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, the Russian Federation., Morozova T; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, the Russian Federation., Kromhout H; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Kovalevskiy E; Federal State Budgetary Scientific Institution 'Izmerov Research Institute of Occupational Health' (IRIOH), Moscow, the Russian Federation.; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, the Russian Federation.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Jul 29; Vol. 15 (7), pp. e0236475. Date of Electronic Publication: 2020 Jul 29 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0236475
Abstrakt: A historical cohort study in workers occupationally exposed to chrysotile was set up in the town of Asbest, the Russian Federation, to study their cause-specific mortality, with a focus on cancer. Chrysotile has different chemical and physical properties compared with other asbestos fibres; therefore it is important to conduct studies specifically of chrysotile and in different geographical regions to improve the knowledge about its carcinogenicity. Setting was the town of Asbest, Sverdlovsk oblast, the Russian Federation. Participants were all current and former employees with at least one year of employment between 1/1/1975 and 31/12/2010 in the mine, enrichment factories, auto-transport and external rail transportation departments, the central laboratory, and the explosives unit of the company. Of the 35,837 cohort members, 12,729 (35.5%) had died (2,373 of them of cancer, including 10 of mesothelioma), 18,799 (52.5%) were known to be alive at the end of the observation period (2015), and 4,309 (12.0%) were censored before the end of 2015. Mean follow-up duration was 21.7 years in men and 25.9 years in women. The mean age at death was 59.4 years in men and 66.5 years in women. This is the largest occupational cohort of chrysotile workers to date, and the only one with a large proportion of exposed female workers.
Competing Interests: Dr Kovalevskiy and Dr Kashanskiy reported receiving, on behalf of their institutes and personally through consulting firms, payments from companies to evaluate exposure to asbestos and risk of asbestos-related disease in those workplaces. All other authors have no competing interests to declare. For full transparency, Dr Kovalevskiy reported participation as an occupational and environmental health expert as part of the delegation of the Russian Ministry of Health at multiple World Health Assembly meetings as well as at the Conference of the Parties to the Basel and Rotterdam Conventions. Dr Kovalevskiy and Dr Kashansky reported attending meetings organized by the International Chrysotile Association and reported that all expenses for attendance were paid by their respective institutes. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Databáze: MEDLINE
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