What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.

Autor:	Ching CRK; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Hibar DP; Genentech, Inc., South San Francisco, California, USA., Gurholt TP; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway., Nunes A; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Abé C; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Agartz I; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Brouwer RM; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Cannon DM; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., de Zwarte SMC; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Eyler LT; Department of Psychiatry, University of California, La Jolla, California, USA.; Desert-Pacific MIRECC, VA San Diego Healthcare, San Diego, California, USA., Favre P; INSERM U955, team 15 'Translational Neuro-Psychiatry', Créteil, France.; Neurospin, CEA Paris-Saclay, team UNIACT, Gif-sur-Yvette, France., Hajek T; Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.; National Institute of Mental Health, Klecany, Czech Republic., Haukvik UK; Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway., Houenou J; INSERM U955, team 15 'Translational Neuro-Psychiatry', Créteil, France.; Neurospin, CEA Paris-Saclay, team UNIACT, Gif-sur-Yvette, France.; APHP, Mondor University Hospitals, DMU IMPACT, Créteil, France., Landén M; Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lett TA; Department for Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Neurology with Experimental Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany., McDonald C; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Nabulsi L; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Patel Y; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada., Pauling ME; Desert-Pacific MIRECC, VA San Diego Healthcare, San Diego, California, USA.; INSERM U955, team 15 'Translational Neuro-Psychiatry', Créteil, France., Paus T; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada., Radua J; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden., Soeiro-de-Souza MG; Mood Disorders Unit (GRUDA), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Tronchin G; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands., Vieta E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Walter H; Department for Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany., Zeng LL; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; College of Intelligence Science and Technology, National University of Defense Technology, Changsha, China., Alda M; Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway., Almeida J; Dell Medical School, The University of Texas at Austin, Austin, Texas, USA., Alnaes D; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; CIBERSAM, Madrid, Spain., Altimus C; Milken Institute Center for Strategic Philanthropy, Washington, District of Columbia, USA., Bauer M; Department of Psychiatry and Psychotherapy, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Bearden CE; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.; Department of Psychology, University of California, Los Angeles, California, USA., Bellani M; Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Benedetti F; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Berk M; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.; IMPACT Institute - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia., Bilderbeck AC; The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne, Orygen, Melbourne, Victoria, Australia.; P1vital Ltd, Wallingford, UK., Blumberg HP; Department of Psychiatry, University of Oxford, Oxford, UK., Bøen E; Mood Disorders Research Program, Yale School of Medicine, New Haven, Connecticut, USA., Bollettini I; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Del Mar Bonnin C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Brambilla P; Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; CIBERSAM, Madrid, Spain.; Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Caseras X; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Dandash O; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia.; Brain, Mind and Society Research Hub, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany., Delvecchio G; Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway., Díaz-Zuluaga AM; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Dima D; Department of Psychology, School of Social Sciences and Arts, City, University of London, London, UK.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Duchesnay É; INSERM U955, team 15 'Translational Neuro-Psychiatry', Créteil, France., Elvsåshagen T; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fears SC; Center for Neurobehavioral Genetics, Los Angeles, California, USA.; Greater Los Angeles Veterans Administration, Los Angeles, California, USA., Frangou S; Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Fullerton JM; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Glahn DC; Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Goikolea JM; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Green MJ; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Grotegerd D; Department of Psychiatry, University of Münster, Münster, Germany., Gruber O; Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Haarman BCM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Henry C; Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neurosciences, Paris, France.; Université de Paris, Paris, France., Howells FM; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Ives-Deliperi V; Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Jansen A; Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Kircher TTJ; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Knöchel C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany., Kramer B; Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Lafer B; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., López-Jaramillo C; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.; Mood Disorders Program, Hospital Universitario Trastorno del Ánimo, Medellín, Colombia., Machado-Vieira R; Experimental Therapeutics and Molecular Pathophysiology Program, Department of Psychiatry, UTHealth, University of Texas, Houston, Texas, USA., MacIntosh BJ; Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Melloni EMT; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Nenadic I; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Nery F; University of Cincinnati, Cincinnati, Ohio, USA.; Universidade de São Paulo, São Paulo, SP, Brazil., Nugent AC; MEG Core Facility, Bethesda, Maryland, USA., Oertel V; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany., Ophoff RA; UCLA Center for Neurobehavioral Genetics, Los Angeles, California, USA.; Department of Psychiatry, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands., Ota M; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Overs BJ; Neuroscience Research Australia, Randwick, New South Wales, Australia., Pham DL; Milken Institute Center for Strategic Philanthropy, Washington, District of Columbia, USA., Phillips ML; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Pineda-Zapata JA; Research Group, Instituto de Alta Tecnología Médica (IATM), Medellín, Colombia., Poletti S; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Polosan M; University of Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.; INSERM U1216 - Grenoble Institut des Neurosciences, La Tronche, France., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; CIBERSAM, Madrid, Spain., Pouchon A; University of Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France., Quidé Y; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Rive MM; Department of Psychiatry, Amsterdam UMC, location AMC, Amsterdam, The Netherlands., Roberts G; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Ruhe HG; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; CIBERSAM, Madrid, Spain., Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.; CIBERSAM, Madrid, Spain., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Schene AH; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Soares JC; Center of Excellent on Mood Disorders, UTHealth Houston, Houston, Texas, USA.; Department of Psychiatry and Behavioral Sciences, UTHealth Houston, Houston, Texas, USA., Stäblein M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany., Stein DJ; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.; SAMRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Tamnes CK; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway., Thomaidis GV; Papanikolaou General Hospital, Thessaloniki, Greece.; Laboratory of Mechanics and Materials, School of Engineering, Aristotle University, Thessaloniki, Greece., Upegui CV; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Veltman DJ; Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands., Wessa M; Department of Neuropsychology and Clinical Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany., Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Department of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Whalley HC; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Wolf DH; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Wu MJ; Department of Psychiatry and Behavioral Sciences, UTHealth Houston, Houston, Texas, USA., Yatham LN; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada., Zarate CA; Chief Experimental Therapeutics & Pathophysiology Branch, Bethesda, Maryland, USA.; Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2022 Jan; Vol. 43 (1), pp. 56-82. Date of Electronic Publication: 2020 Jul 29.
DOI:	10.1002/hbm.25098
Abstrakt:	MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness. (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze:	MEDLINE
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