| Autor: |
Frade VP; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Simões NS; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Couto NRB; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Sanches C; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Oliveira CDL; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2020; Vol. 62, pp. e52. Date of Electronic Publication: 2020 Jul 24. |
| DOI: |
10.1590/s1678-9946202062052 |
| Abstrakt: |
The present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: "Chagas disease", "benznidazole", "Drug Therapy", "Pharmacokinetics", "Dose-response relationship, drug" and "Chronic disease". The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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