Evaluation of the Diagnostic and Predicative Values of 8-Iso-Prostaglandin F2α as a Biomarker of Breast Cancer.

Autor: Nour Eldin EEM; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Nour Eldein MM; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.; Faculty of Medicine, Ain Shams University, Cairo, Egypt., El-Readi MZ; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Mirza AA; Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia, aamirza1@kau.edu.sa.; Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, aamirza1@kau.edu.sa., Fatani SH; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Al-Amodi HS; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Althubiti MA; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Al-Ezzi EM; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Eid SY; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Kamel HFM; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Oncology research and treatment [Oncol Res Treat] 2020; Vol. 43 (10), pp. 506-517. Date of Electronic Publication: 2020 Jul 28.
DOI: 10.1159/000509671
Abstrakt: Background: Breast cancer (BC) is a commonly reported cancer that is widely prevalent among women. Its early detection improves patient survival and results in better outcomes. For diagnosis and follow-up care, tumor markers are one of the feasible investigations to be ordered. 8-Iso-prostaglandin F2α (8-iso-PGF2α) serves as a serum marker reflecting oxidative stress and subsequent damaging of DNA. In the present study, we aimed to evaluate both diagnostic and predictive values of 8-iso-PGF2α in BC patients.
Materials and Methods: Serum levels of 8-iso-PGF2α were assessed for 66 women with benign breast tumors and 65 women who had malignant BC. To compare the patients who had breast tumors with healthy individuals, 63 women free of breast diseases were selected as controls.
Results: The serum level of 8-iso-PGF2α in the BC patients (57.92 pg/mL) was significantly higher compared to those with benign tumors (18.89 pg/mL) (p < 0.001). In addition, individuals with no breast diseases had less 8-iso-PGF2α (4.02 pg/mL) compared to those who had developed a tumor (p < 0.001). Serum 8-iso-PGF2α was found to be positively correlated with both carcinoembryonic antigen (r = 0.74, p < 0.001) and cancer antigen 15-3 (r = 0.80, p < 0.001). Furthermore, serum 8-iso-PGF2α showed high diagnostic performance in BC (AUC = 0.999, sensitivity = 100%, specificity = 99.2% at a cutoff value of 36.18 pg/mL).
Conclusions: Our study found that the high level of serum 8-iso-PGF2α helps to provide a non-invasive indicator to detect BC. Future work with a larger sample size and various phases of BC can confirm the current results which provide insights into the early detection of cancer.
(© 2020 S. Karger AG, Basel.)
Databáze: MEDLINE
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