The home air in agriculture pediatric intervention (HAPI) trial: Rationale and methods.

Autor: Masterson EE; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America. Electronic address: emaster@uw.edu., Younglove LB; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Perez A; Yakima Valley Farm Worker's Clinic, Toppenish, WA, United States of America., Torres E; Northwest Communities Education Center, Radio KDNA, Granger, WA, United States of America., Krenz JE; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Tchong French MI; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Riederer AM; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Sampson PD; Department of Statistics, University of Washington, Seattle, WA, United States of America., Metwali N; Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States of America., Min E; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Jansen KL; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Aisenberg G; School of Social Work, University of Washington, Seattle, WA, United States of America., Babadi RS; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Farquhar SA; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America; Department of Health Services, University of Washington, Seattle, WA, United States of America., Thorne PS; Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States of America., Karr CJ; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, United States of America; Department of Pediatrics, University of Washington, Seattle, WA, United States of America.
Jazyk: angličtina
Zdroj: Contemporary clinical trials [Contemp Clin Trials] 2020 Sep; Vol. 96, pp. 106085. Date of Electronic Publication: 2020 Jul 25.
DOI: 10.1016/j.cct.2020.106085
Abstrakt: Background: Data addressing air quality effects on children with asthma in rural U.S. communities are rare. Our community engaged research partnership previously demonstrated associations between neighborhood NH 3 and ambient PM 2.5 and asthma in the agricultural lower Yakima Valley of Washington. As a next step, the partnership desired an intervention approach to address concerns about pediatric asthma in this largely Latino immigrant, farm worker community.
Objective: The Home Air in Agriculture Pediatric Intervention (HAPI) sought to examine the effectiveness of enrichment of an existing asthma education program with portable high-efficiency particulate air (HEPA) cleaners designed to reduce PM 2.5 and NH 3. We investigated the effect of this enriched approach on these exposures and asthma health measures.
Design: We randomized children with poorly controlled asthma to a control arm (current asthma education program) or an intervention arm (current asthma education program + placement of two indoor air cleaners in the family's home). Outcomes included (1) 14-day integrated samples of indoor air contaminants (PM 2.5 and NH 3 ) at baseline and one-year follow-up and (2) child asthma health metrics at baseline, midpoint (4-6 months) and one-year follow-up. These included the Asthma Control Test, symptoms days, clinical utilization, oral corticosteroid use, pulmonary function, fractional exhaled nitric oxide, and urinary leukotriene E 4 concentration.
Discussion: To our knowledge, this is the first randomized HEPA cleaner intervention designed to assess NH 3 as well as PM 2.5 and to evaluate health outcomes of children with asthma in an agricultural region.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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