Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.

Autor: Tang Y; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Centre de Neurosciences Psychiatriques, Centre Hospitalier Universitaire Vaudois (CHUV), Prilly (Lausanne), Switzerland., Benusiglio D; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Lefevre A; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Centre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France., Hilfiger L; Centre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France., Althammer F; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA., Bludau A; Department of Neurobiology and Animal Physiology, University of Regensburg, Regensburg, Germany., Hagiwara D; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Baudon A; Centre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France., Darbon P; Centre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France., Schimmer J; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Kirchner MK; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA., Roy RK; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA., Wang S; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Eliava M; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Wagner S; Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa, Israel., Oberhuber M; Max von Pettenkofer-Institute Virology, Faculty of Medicine and Gene Center, Ludwig Maximilian University, Munich, Germany., Conzelmann KK; Max von Pettenkofer-Institute Virology, Faculty of Medicine and Gene Center, Ludwig Maximilian University, Munich, Germany., Schwarz M; Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Center, Bonn, Germany., Stern JE; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA., Leng G; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Neumann ID; Department of Neurobiology and Animal Physiology, University of Regensburg, Regensburg, Germany., Charlet A; Centre National de la Recherche Scientifique, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France. acharlet@unistra.fr., Grinevich V; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. valery.grinevich@zi-mannheim.de.; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA. valery.grinevich@zi-mannheim.de.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2020 Sep; Vol. 23 (9), pp. 1125-1137. Date of Electronic Publication: 2020 Jul 27.
DOI: 10.1038/s41593-020-0674-y
Abstrakt: Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons.
Databáze: MEDLINE
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