Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region.

Autor: Noviyanti R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Miotto O; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Barry A; School of Medicine, Deakin University, Geelong, VIC, Australia.; Burnet Institute, Melbourne, VIC, Australia.; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Marfurt J; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Siegel S; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Thuy-Nhien N; Centre for Tropical Medicine, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Quang HH; Institute of Malariology, Parasitology and Entomology, Quy Nhon, Vietnam., Anggraeni ND; National Malaria Control Programme, Ministry of Health, Jakarta, Indonesia., Laihad F; UNICEF Indonesia Country Office, Jakarta, Indonesia., Liu Y; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, China., Sumiwi ME; UNICEF Indonesia Country Office, Jakarta, Indonesia., Trimarsanto H; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Coutrier F; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Fadila N; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Ghanchi N; Pathology, Aga Khan University Hospital, Karachi, Pakistan., Johora FT; Infectious Diseases Division, International Centre for Diarrheal Diseases Research, Bangladesh Mohakhali, Dhaka, Bangladesh., Puspitasari AM; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Tavul L; Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea., Trianty L; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Utami RAS; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Wang D; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China., Wangchuck K; Royal Center for Disease Control, Department of Public Health, Ministry of Health, Thimphu, Bhutan., Price RN; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Auburn S; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. sarah.auburn@menzies.edu.au.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. sarah.auburn@menzies.edu.au.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. sarah.auburn@menzies.edu.au.
Jazyk: angličtina
Zdroj: Malaria journal [Malar J] 2020 Jul 27; Vol. 19 (1), pp. 271. Date of Electronic Publication: 2020 Jul 27.
DOI: 10.1186/s12936-020-03330-5
Abstrakt: The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes (NMCPs) in decision-making processes. In November 2019 a parasite genotyping workshop was held in Jakarta, Indonesia, to review molecular approaches for parasite surveillance and explore ways in which these tools can be integrated into public health systems and inform policy. The meeting was attended by 70 participants from 8 malaria-endemic countries and partners of the Asia Pacific Malaria Elimination Network. The participants acknowledged the utility of multiple use cases for parasite genotyping including: quantifying the prevalence of drug resistant parasites, predicting risks of treatment failure, identifying major routes and reservoirs of infection, monitoring imported malaria and its contribution to local transmission, characterizing the origins and dynamics of malaria outbreaks, and estimating the frequency of Plasmodium vivax relapses. However, the priority of each use case varies with different endemic settings. Although a one-size-fits-all approach to molecular surveillance is unlikely to be applicable across the Asia-Pacific region, consensus on the spectrum of added-value activities will help support data sharing across national boundaries. Knowledge exchange is needed to establish local expertise in different laboratory-based methodologies and bioinformatics processes. Collaborative research involving local and international teams will help maximize the impact of analytical outputs on the operational needs of NMCPs. Research is also needed to explore the cost-effectiveness of genetic epidemiology for different use cases to help to leverage funding for wide-scale implementation. Engagement between NMCPs and local researchers will be critical throughout this process.
Databáze: MEDLINE
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