| Autor: |
Baranowski BJ; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada., Marko DM; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada., Fenech RK; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada., Yang AJT; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada., MacPherson REK; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.; Centre for Neuroscience, Brock University, St. Catharines, ON L2S 3A1, Canada. |
| Jazyk: |
angličtina |
| Zdroj: |
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2020 Oct; Vol. 45 (10), pp. 1055-1065. Date of Electronic Publication: 2020 Jul 27. |
| DOI: |
10.1139/apnm-2019-0910 |
| Abstrakt: |
With the world's population aging at a rapid rate, the prevalence of Alzheimer's disease (AD) has significantly increased. These statistics are alarming given recent evidence that a third of dementia cases may be preventable. The role of lifestyle factors, such as diet and exercise, can directly alter the risk of disease development. However, an understanding of the effectiveness of dietary patterns and exercise strategies to reduce AD risk or improve brain function is not fully understood. The aim of this review is to discuss the effects of diet and exercise on AD risk. Key components of the Western and Mediterranean diets are discussed in relation to AD progression, as well as how physical activity promotes brain health. Components of the Western diet (saturated fatty acids and simple carbohydrates) are detrimental to the brain, impair cognition, and increase AD pathologies. While components of the Mediterranean diet (polyunsaturated fatty acids, polyphenols, and antioxidants) are considered to be neuroprotective. Exercise can significantly reduce the risk of AD; however, specific exercise recommendations for older adults are limited and optimal intensity, duration, and type remains unknown. This review highlights important modifiable risk factors for AD and points out potential avenues for future research. Novelty Diet and exercise are modifiable factors that can improve brain health and reduce the risk of AD. Polyunsaturated fatty acids, polyphenols, and antioxidants are neuroprotective. Exercise reduces neuroinflammation, improves brain insulin sensitivity, and increases brain derived neurotrophic factor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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