Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis.

Autor:	Garelli CJ; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States., Refat MA; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States., Nanaware PP; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, United States., Ramirez-Ortiz ZG; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States., Rashighi M; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States., Richmond JM; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2020 Jul 02; Vol. 11, pp. 1353. Date of Electronic Publication: 2020 Jul 02 (Print Publication: 2020).
DOI:	10.3389/fimmu.2020.01353
Abstrakt:	Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches. (Copyright © 2020 Garelli, Refat, Nanaware, Ramirez-Ortiz, Rashighi and Richmond.)
Databáze:	MEDLINE
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