Morin attenuates STZ-induced diabetic retinopathy in experimental animals.

Autor:	Jiang B; Department of Ophthalmology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai 201508, China., Geng Q; Department of Eye Fundus,Liaocheng Guangming Ophthalmological Hospital, Liaocheng, Shandong 252000, China., Li T; Department of Ophthalmology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai 201508, China., Mohammad Firdous S; Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal, India., Zhou X; Department of Ophthalmology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai 201508, China.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2020 Aug; Vol. 27 (8), pp. 2139-2142. Date of Electronic Publication: 2020 Jun 08.
DOI:	10.1016/j.sjbs.2020.06.001
Abstrakt:	Diabetic retinopathy (DR) occurs in untreated diabetic patients due to the strong influence of oxidative stress. Bioflavonoids are well known for their antioxidant property. Morin, a bioflavonoid, has been demonstrated for its antioxidant as well as antidiabetic activity. Thus, this research work intended to determine the ameliorative impact of morin in DR rats using STZ-induced type 1 diabetic model. To induce type 1 diabetic in rats STZ (60 mg/kg) was administered intraperitoneally. Grouping of animals was done as described below (n = 6), where, group I - normal control, group II - diabetic control, group III - morin (25 mg/kg), group IV - morin (50 mg/kg), and group V - metformin (350 mg/kg) were used. All the animals underwent treatment for 60 days as given above. It was observed that supplementation of morin (25 and 50 mg/kg) showed a noteworthy decline in elevated serum glucose level. Moreover, decrease in the level of LPO and improved activity of endogenous antioxidants (GPx, CAT, and SOD) was observed in morin treated groups. It also notably drops the concentration of TNF-α, IL-1β, and VEGF in the tissue homogenate of the retina. Furthermore, it increased the retinal thickness and cell count in the ganglion cell layer of the retina in diabetic animals. Hence, we can conclude that morin encumbers the progression of DR in diabetic animals, which may be via antioxidant property and suppression of TNF-α, IL-1β, and VEGF. (© 2020 The Authors.)
Databáze:	MEDLINE
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