Anogenital distance and anti-Müllerian hormone combined improves the diagnosis of polycystic ovary syndrome.

Autor: Prieto-Sánchez MT; Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain.; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, Murcia, Spain., Hernández-Peñalver AI; Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain., Sánchez-Ferrer ML; Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain.; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, Murcia, Spain., Mendiola J; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, Murcia, Spain.; Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, Murcia, Spain.; Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Madrid, Spain., Torres-Cantero AM; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, Murcia, Spain.; Division of Preventive Medicine and Public Health, Department of Public Health Sciences, University of Murcia School of Medicine, Murcia, Spain.; Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Preventive Medicine, 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain.
Jazyk: angličtina
Zdroj: Human fertility (Cambridge, England) [Hum Fertil (Camb)] 2022 Apr; Vol. 25 (2), pp. 274-282. Date of Electronic Publication: 2020 Jul 27.
DOI: 10.1080/14647273.2020.1795574
Abstrakt: The objective of this study was to assess the accuracy of the combination of anogenital distance (AGD) and anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS). The study included women diagnosed with PCOS and a control group who attended the Clinical University Hospital 'Virgen de la Arrixaca' in Murcia (Spain). Serum concentrations of AMH were measured and two AGD measurements were obtained: (i) from the anterior clitoral surface to the upper verge of the anus (AGD AC ); and (ii) from the posterior fourchette to the upper verge of the anus (AGD AF ). Data were assessed by receiver operator characteristic (ROC) curves. Women with PCOS ( n  = 126) had significantly larger AGD AC (80.5 ± 11.3 versus 76.0 ± 10.4 mm; p  < 0.001) and higher AMH (7.2 ± 4.7 versus 3.1 ± 2.2; p  < 0.001) compared to control women ( n  = 159). Women with serum AMH above 3.8 ng/mL (clinical cut-off used in PCOS) were 9.1 times more likely to have PCOS (95% CI: 5.1-16.2). The area under the ROC curve of combined model of AMH and AGD AC was 0.87 (95% CI: 0.83-0.91). The combined model for predicting PCOS based on AMH and AGD AC has better diagnostic accuracy than that of AMH or AGD AC alone. This model could be useful for clinicians and improve diagnosis and clinical management of these women.
Databáze: MEDLINE
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