Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis.

Autor:	Gadbail AR; Department of Dentistry, Indira Gandhi Government Medical College and Hospital, Nagpur, Maharashtra, India., Korde S; Department of Oral Pathology and Microbiology, Yerala Dental College and Hospital, Kharghar, Mumbai, India., Chaudhary MS; Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India., Sarode SC; Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune., Gondivkar SM; Department of Oral Medicine and Radiology, Government Dental College and Hospital, Nagpur, Maharashtra, India., Dande R; Department of Dentistry, Indira Gandhi Government Medical College and Hospital, Nagpur, Maharashtra, India., Tekade SA; Department of Oral Pathology and Microbiology, Modern Dental College and Research Centre, Gandhi Nagar, Indore, Madhya Pradesh, India., Yuwanati M; Department of Oral Pathology and Microbiology, People's College of Dental Science & Research Centre, People's University, Bhopal, Madhya Pradesh, India., Hande A; Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India., Patil S; Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2020 Jul 01; Vol. 21 (7), pp. 2067-2074. Date of Electronic Publication: 2020 Jul 01.
DOI:	10.31557/APJCP.2020.21.7.2067
Abstrakt:	Background: The clinicopathological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSF) is well known; however, the molecular distinctness of this unique OSCC-OSF has not been investigated to date. With this in mind, we compared the expression of Ki67, CD105, and α-SMA between OSCC-OSF and oral squamous cell carcinoma (OSCC). Methods: Formalin-fixed paraffin-embedded tissues of 105 OSCC-OSF and 112 OSCC cases were subjected to immunohistochemistry for evaluation of Ki67, CD105, and α-SMA expression. Results: Ki67 (labeling index) LI, MVD and α-SMA expression were significantly higher in OSCC compared to OSCC-OSF. Ki67 LI and MVD was significantly higher in OSCC compared to OSCC-OSF in parameters such as well-differentiated, early TNM stage, non-metastatic, and more than 3-year survival. α-SMA expression was significantly higher in OSCC compared to OSCC-OSF in parameters such as moderate differentiation, metastatic lesions, and survival less than 3 years. Ki67 LI, MVD and α-SMA showed significant positive correlation with each other in OSCC and OSCC-OSF. Conclusion: Proliferation, neoangiogenesis and myofibroblast differentiation were significantly higher in the OSCC group compared to the OSCC-OSF group. This suggests the biological distinctness of OSCC-OSF, which could help the future development of targeted therapies.
Databáze:	MEDLINE
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